Virtual Biopsy by Electrical Impedance Spectroscopy in Barrett's Carcinoma.

Autor: Blößer S; Department of Medicine II, Sana Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach, Germany.; Department of Medicine I, Asklepios Paulinen Klinik Wiesbaden, Geisenheimer Strasse 10, 65197, Wiesbaden, Germany., May A; Department of Medicine II, Sana Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach, Germany.; Department of Medicine I, Asklepios Paulinen Klinik Wiesbaden, Geisenheimer Strasse 10, 65197, Wiesbaden, Germany., Welsch L; Department of Gastroenterology, Medizinische Klinik I, University Hospital, Goethe University, Frankfurt, Germany, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany., Ast M; Stockert GmbH, Bötzinger Strasse 72, 79111, Freiburg, Germany., Braun S; Institute of Pathology, Sana Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach, Germany., Velten T; Fraunhofer Institute for Biomedical Engineering (IBMT), Ensheimer Strasse 48, 66386, St. Ingbert, Germany., Biehl M; Fraunhofer Institute for Biomedical Engineering (IBMT), Ensheimer Strasse 48, 66386, St. Ingbert, Germany., Tschammer J; Institute for Medical Informatics, Justus Liebig University of Giessen, Rudolf-Buchheim-Str. 6, 35392, Giessen, Germany., Roeb E; Department of Gastroenterology, Justus Liebig University of Giessen, Klinikstrasse 33, 35392, Giessen, Germany., Knabe M; Department of Gastroenterology, Medizinische Klinik I, University Hospital, Goethe University, Frankfurt, Germany, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. Mate.Knabe@kgu.de.
Jazyk: angličtina
Zdroj: Journal of gastrointestinal cancer [J Gastrointest Cancer] 2022 Dec; Vol. 53 (4), pp. 948-957. Date of Electronic Publication: 2021 Sep 24.
DOI: 10.1007/s12029-021-00703-0
Abstrakt: Purpose: Early detection of adenocarcinomas in the esophagus is crucial for achieving curative endoscopic therapy. Targeted biopsies of suspicious lesions, as well as four-quadrant biopsies, represent the current diagnostic standard. However, this procedure is time-consuming, cost-intensive, and examiner-dependent. The aim of this study was to test whether impedance spectroscopy is capable of distinguishing between healthy, premalignant, and malignant lesions. An ex vivo measurement method was developed to examine esophageal lesions using impedance spectroscopy immediately after endoscopic resection.
Methods: After endoscopic resection of suspicious lesions in the esophagus, impedance measurements were performed on resected cork-covered tissue using a measuring head that was developed, with eight gold electrodes, over 10 different measurement settings and with frequencies from 100 Hz to 1 MHz.
Results: A total of 105 measurements were performed in 60 patients. A dataset of 400 per investigation and a total of more than 42,000 impedance measurements were therefore collected. Electrical impedance spectroscopy (EIS) was able to detect dysplastic esophageal mucosa with a sensitivity of 81% in Barrett's esophagus.
Conclusion: In summary, EIS was able to distinguish different tissue characteristics in the different esophageal tissues. EIS thus holds potential for further development of targeted biopsies during surveillance endoscopy. Trial Registration NCT04046601.
(© 2021. The Author(s).)
Databáze: MEDLINE
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