Mechanisms and clinical importance of bacteriophage resistance.

Autor:	Egido JE; Medical Microbiology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, Netherlands., Costa AR; Department of Bionanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, Netherlands.; Kavli Institute of Nanoscience, van der Maasweg 9, 2629 HZ Delft, Netherlands.; Fagenbank, van der Maasweg 9, 2629 HZ Delft, Netherlands., Aparicio-Maldonado C; Department of Bionanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, Netherlands.; Kavli Institute of Nanoscience, van der Maasweg 9, 2629 HZ Delft, Netherlands., Haas PJ; Medical Microbiology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, Netherlands., Brouns SJJ; Department of Bionanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, Netherlands.; Kavli Institute of Nanoscience, van der Maasweg 9, 2629 HZ Delft, Netherlands.; Fagenbank, van der Maasweg 9, 2629 HZ Delft, Netherlands.
Jazyk:	angličtina
Zdroj:	FEMS microbiology reviews [FEMS Microbiol Rev] 2022 Feb 09; Vol. 46 (1).
DOI:	10.1093/femsre/fuab048
Abstrakt:	We are in the midst of a golden age of uncovering defense systems against bacteriophages. Apart from the fundamental interest in these defense systems, and revolutionary applications that have been derived from them (e.g. CRISPR-Cas9 and restriction endonucleases), it is unknown how defense systems contribute to resistance formation against bacteriophages in clinical settings. Bacteriophages are now being reconsidered as therapeutic agents against bacterial infections due the emergence of multidrug resistance. However, bacteriophage resistance through defense systems and other means could hinder the development of successful phage-based therapies. Here, we review the current state of the field of bacteriophage defense, highlight the relevance of bacteriophage defense for potential clinical use of bacteriophages as therapeutic agents and suggest new directions of research. (© The Author(s) 2021. Published by Oxford University Press on behalf of FEMS.)
Databáze:	MEDLINE
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