Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation.

Autor:	Salman A; Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Aon M; Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Hussein A; Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Salman M; General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Tourky M; Department of Surgery, Great Western Hospitals NHS Foundation Trust, Swindon, UK., Mahmoud A; Senior Clinical Fellow, Great Western Hospital NHS Foundation Trust, Swindon, UK., Aljarad F; Lewisham and Greenwich NHS Trust, Lewisham, London, UK., Elkaseer M; General Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Shaaban HE; Hepatology and Gastroenterology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt., Moustafa A; Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt., El-Mikkawy A; Hepatology and Gastroenterology Department, Theodor Bilharz Research Institute, Cairo, Egypt., Gaballa N; Anesthesiology and Intensive Care Department, National Liver Institute, Menoufia University, Shibin El Kom, Egypt., Abdallah H; Clinical Pathology Department, National Liver Institute, Menoufia University, Shibin El Kom, Egypt., Zaky Rashed ZF; Anesthesiology and Intensive Care Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.; Department of Anesthesia, College of Applied Sciences, Almaarefa university, Ad Diriyah, Riyadh, Saudi Arabia., Elkassar H; Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	International journal of general medicine [Int J Gen Med] 2021 Sep 16; Vol. 14, pp. 5711-5718. Date of Electronic Publication: 2021 Sep 16 (Print Publication: 2021).
DOI:	10.2147/IJGM.S326315
Abstrakt:	Background: This work endeavored to explore the effect of hypothyroidism on mortality in subjects with HCC who underwent living-donor liver transplantation (LDLT). Methods: This prospective study included 107 patients with HCC subjected to LDLT, divided into hypothyroid group (n=53) and euthyroid group (n=54). The primary objectives were overall and disease-free survival (DFS). Results: Euthyroid and hypothyroid groups were comparable in all baseline characteristics except the age of patients. Overall survival (OS) of the whole group at 48 months was 68.8%, while the DFS was 60.2%. On univariate analysis, OS was negatively affected by the older age of the patients (p<0.001) or the donor (p<0.001), hypothyroidism (p=0.008), HBV (p=0.029), larger tumor size (p=0.023), and defective Milan criteria (p=0.022). On multivariate analysis, the age of the patients and donors was the independent factor affecting OS. On univariate analysis, DFS was negatively affected by older age of the patients (p < 0.001) or the donor (p=0.005), hypothyroidism (p=0.005), HBV (p=0.019), larger tumor size (p=0.023), and defective Milan criteria (p=0.020). On multivariate analysis, the age of the patients, thyroid status, and Milan criteria were the independent factors affecting DFS. Conclusion: Hypothyroidism is a risk factor for worse outcomes in HCC patients after liver transplantation. Competing Interests: The authors declare that there is no conflicts of interest in this work. (© 2021 Salman et al.)
Databáze:	MEDLINE
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