Prevalence and risk factors of chronic kidney disease in an HIV positive Mexican cohort.

Autor: Valdivia-Cerda V; Servicio de Nefrología, Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Guadalajara, Jalisco, Mexico., Alvarez-Zavala M; Universidad de Guadalajara, Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Centro Universitario de Ciencias de La Salud, Jalisco, México., Sánchez-Reyes K; Universidad de Guadalajara, Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Centro Universitario de Ciencias de La Salud, Jalisco, México., Cabrera-Silva RI; Universidad de Guadalajara, Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Centro Universitario de Ciencias de La Salud, Jalisco, México., Ruiz-Herrera VV; Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Unidad de VIH, Guadalajara, Jalisco, Mexico., Loza-Salazar AD; Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Unidad de VIH, Guadalajara, Jalisco, Mexico., Martínez-Ayala P; Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Unidad de VIH, Guadalajara, Jalisco, Mexico., Vázquez-Limón JC; Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Unidad de VIH, Guadalajara, Jalisco, Mexico., García-García G; Servicio de Nefrología, Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Guadalajara, Jalisco, Mexico., Andrade-Villanueva JF; Universidad de Guadalajara, Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Centro Universitario de Ciencias de La Salud, Jalisco, México.; Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Unidad de VIH, Guadalajara, Jalisco, Mexico., González-Hernández LA; Universidad de Guadalajara, Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Centro Universitario de Ciencias de La Salud, Jalisco, México. luceroga08@gmail.com.; Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Unidad de VIH, Guadalajara, Jalisco, Mexico. luceroga08@gmail.com.
Jazyk: angličtina
Zdroj: BMC nephrology [BMC Nephrol] 2021 Sep 23; Vol. 22 (1), pp. 317. Date of Electronic Publication: 2021 Sep 23.
DOI: 10.1186/s12882-021-02526-4
Abstrakt: Background: HIV subjects have several kidney pathologies, like HIV-associated nephropathy or antiretroviral therapy injury, among others. The global prevalence of Chronic Kidney Disease (CKD) is 8-16%; however, in HIV subjects, the prevalence varies between geographic regions (2-38%). The aim was to determine the prevalence of CKD and identify the associated risk factors.
Methods: A longitudinal descriptive study was carried out at the 'Hospital Civil de Guadalajara' Feb'18 - Jan'19. Basal clinical, demographic, opportunistic infections (OI), and laboratory data were obtained at months 0 and 3; inclusion criteria were ≥ 18 years old, naïve HIV + , urine albumin/creatinine ratio, serum creatinine & urine test, and signed informed consent. Descriptive and multiple logistic regression statistical analyses were made.
Results: One hundred twenty subjects were included; 92.5% were male, 33 ± 9.5 years, 60% consumed tobacco, 73% alcohol, and 59% some type of drug. The CKD prevalence was 15.8%. CKD patients had a higher risk of hepatitis C virus coinfection, Relative Risk (RR):5.9; HCV infection, RR:4.3; ≥ 30 years old, RR:3.9; C clinical-stage, RR:3.5; CD4 +  T cells count < 200 cells/μL, RR: 2.4; and HIV-1 viral load ≥ 100,000 cop/mL, RR: 2.7.
Conclusions: Our study showed a higher CKD prevalence in patients with HIV; higher CKD development with coinfections as Hepatitis C Virus and Mycobacterium tuberculosis. The identification and prompt management of CKD and coinfections should be considered to avoid the progression and to delay renal replacement therapy as long as possible.
(© 2021. The Author(s).)
Databáze: MEDLINE
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