Modulatory role of genistein on placenta and maternal bone minerals composition: further insight into its influence on pregnancy and foetal development.

Autor: Samuel TA; Department of Biochemistry, College of Medicine, University of Lagos, Lagos, Nigeria., Awobajo FO; Department of Physiology, College of Medicine, University of Lagos, Lagos, Nigeria. fawobajo@unilag.edu.ng., Akinsanya TH; Department of Biochemistry, College of Medicine, University of Lagos, Lagos, Nigeria., Oyediran HS; Department of Physiology, College of Medicine, University of Lagos, Lagos, Nigeria., Egege IE; Department of Biochemistry, College of Medicine, University of Lagos, Lagos, Nigeria., Egede CB; Department of Physiology, College of Medicine, University of Lagos, Lagos, Nigeria., Timothy BO; Department of Physiology, College of Medicine, University of Lagos, Lagos, Nigeria.
Jazyk: angličtina
Zdroj: Biologia futura [Biol Futur] 2020 Sep; Vol. 71 (3), pp. 223-230. Date of Electronic Publication: 2020 Jun 25.
DOI: 10.1007/s42977-020-00017-5
Abstrakt: Pregnancy is a crucial period with an increased need to supply necessary minerals for both the mother and the developing foetus and with a tendency of altering the maternal bone mineral density when there is no balance between demand and supply of these minerals. This study evaluated the influence of genistein on the maternal bone and placenta mineral composition. Pregnant rats were grouped into control, 2 mg/kg and 4 mg/kg genistein groups, dosed accordingly till sacrificed at different gestation days (GD). Body and placenta weights, right femur bone and placenta mineral composition were analysed. A significant decrease in body weight and percentage relative right femur bone weight at GD-20 was recorded in the 2-mg group with the reverse occurring in the 4-mg genistein group. The right femur bone Ca 2+ and Zn 2+ was reduced towards GD-20 in both 2-mg and 4-mg genistein groups. Genistein had no influence on placenta selenium and cadmium level, but significantly decreased zinc and lead level concentration as the gestation progressed towards GD-20. Copper level was increased at GD-16 at the doses used. Genistein modulated maternal bone mineral composition and placenta capability in retaining some heavy metals at various stages of pregnancy.
(© 2020. Akadémiai Kiadó Zrt.)
Databáze: MEDLINE
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