Ruthenium(II)-catalyzed C-H activation and (4+2) annulation of aromatic hydroxamic acid esters with allylic amides.
Autor: | Giri CK; Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, Tamil Nadu, India. mbaidya@iitm.ac.in., Dana S; Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, Tamil Nadu, India. mbaidya@iitm.ac.in., Baidya M; Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, Tamil Nadu, India. mbaidya@iitm.ac.in. |
---|---|
Jazyk: | angličtina |
Zdroj: | Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Oct 12; Vol. 57 (81), pp. 10536-10539. Date of Electronic Publication: 2021 Oct 12. |
DOI: | 10.1039/d1cc04422b |
Abstrakt: | A (4+2) annulation under Ru(II)-catalysis is reported using aromatic hydroxamic acid esters as the oxidizing directing group and allylic amides as unactivated olefin coupling partners, delivering a wide variety of aminomethyl isoquinolinones in good to excellent yields. This annulation is distinctive as allylic congeners typically result in allylation and not the annulation. Late-stage derivatization of a bioactive synthetic bile acid has been showcased. |
Databáze: | MEDLINE |
Externí odkaz: |