The Association of Human Leukocyte Antigen and COVID-19 in Southern China.

Autor: Yu X; Department of Infectious Disease, The First Hospital of Quanzhou, affiliated to Fujian Medical University, Quanzhou, Fujian, China., Ho K; HI. Q Biomedical Laboratory, Quanzhou, Fujian, China.; School of Biomedical Science, Huaqiao University, Quanzhou, Fujian, China., Shen Z; Department of Infectious Disease, Huashan Hospital, Fudan University, Shanghai, China., Fu X; HI. Q Biomedical Laboratory, Quanzhou, Fujian, China., Huang H; Department of Respiratory Disease, The First Hospital of Quanzhou, affiliated to Fujian Medical University, Quanzhou, Fujian, China., Wu D; HI. Q Biomedical Laboratory, Quanzhou, Fujian, China., Lin Y; HI. Q Biomedical Laboratory, Quanzhou, Fujian, China., Lin Y; Department of Respiratory Disease, The First Hospital of Quanzhou, affiliated to Fujian Medical University, Quanzhou, Fujian, China., Chen W; Department of Infectious Disease, The First Hospital of Quanzhou, affiliated to Fujian Medical University, Quanzhou, Fujian, China., Su M; Department of Clinical Laboratory, The First Hospital of Quanzhou, affiliated to Fujian Medical University, Quanzhou, Fujian, China., Qiu C; Department of Infectious Disease, Huashan Hospital, Fudan University, Shanghai, China., Zhuang X; Department of Respiratory Disease, The First Hospital of Quanzhou, affiliated to Fujian Medical University, Quanzhou, Fujian, China., Su Z; Department of Infectious Disease, The First Hospital of Quanzhou, affiliated to Fujian Medical University, Quanzhou, Fujian, China.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2021 Aug 06; Vol. 8 (9), pp. ofab410. Date of Electronic Publication: 2021 Aug 06 (Print Publication: 2021).
DOI: 10.1093/ofid/ofab410
Abstrakt: Human leukocyte antigen (HLA) polymorphism is hypothesized to be associated with diverse immune responses toward infectious diseases. Herein, by comparing against multiple subpopulation groups as control, we confirmed that HLA-B*15:27 and HLA-DRB1*04:06 were associated with coronavirus disease 2019 susceptibility in China. Both alleles were predicted to have weak binding affinities toward viral proteins.
(© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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