Decreased vitamin D levels in obsessive-compulsive disorder patients.

Autor:	Marazziti D; Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy.; Saint Camillus International University of Health and Medical Sciences, Rome, Italy., Barberi FM; Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy., Fontenelle L; Institute of Psychiatry of the Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Psychiatry, School of Clinical Sciences, Monash University, Clayton, VIC, Australia., Buccianelli B; Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy., Carbone MG; Department of Medicine and Surgery, Division of Psychiatry, University of Insubria, Varese, Italy., Parra E; Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy., Palermo S; Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy., Massa L; Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy., Tagliarini C; Department of Mental Health, National Health Service, ASST Cremona, Cremona, Italy., Della Vecchia A; Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy., Mucci F; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy., Arone A; Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy., Dell'Osso L; Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy.
Jazyk:	angličtina
Zdroj:	CNS spectrums [CNS Spectr] 2023 Oct; Vol. 28 (5), pp. 606-613. Date of Electronic Publication: 2021 Sep 23.
DOI:	10.1017/S1092852921000821
Abstrakt:	Objective: The present paper compared vitamin D levels in adult patients with obsessive-compulsive disorder (OCD) and explored possible correlations with patients' characteristics. Methods: Fifty outpatients with OCD, according to DSM-5 criteria, were included and assessed with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and the Hamilton Rating Scale for Depression (HRDS). Results: All the patients except one showed lower vitamin D levels than normative values (>30 nm/L). Vitamin D values of the whole sample were negatively correlated with Y-BOCS total, compulsion subscale, and some items' scores, specifically "interference from obsessions," "distress associated with obsessions," and "time spent on compulsions". The same relationships were detected in men, while women showed negative correlations between vitamin D levels and Y-BOCS compulsion subscale and "resistance to compulsions," "degree of control of compulsions," "insight" item scores. Conclusions: Our findings would indicate that vitamin D might be involved in the pathophysiology of OCD, and that it is possibly related to the severity of the disorder and to typical symptoms, with some sex-related peculiarities. Further studies are necessary to support or not our findings and to ascertain the effectiveness of vitamin D supplementation in patients with OCD.
Databáze:	MEDLINE
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