Cortical Gyrification Morphology in ASD and ADHD: Implication for Further Similarities or Disorder-Specific Features?

Autor:	Gharehgazlou A; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto M4G 1R8, Canada.; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto M5S 1A8, Canada., Vandewouw M; Neuroscience & Mental Health Program, Hospital for Sick Children Research Institute, Toronto M5G 0A4, Canada.; Diagnostic Imaging, The Hospital for Sick Children, Toronto M5G 1X8, Canada.; Autism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto M4G 1R8, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto M5S 3G9, Canada., Ziolkowski J; Neuroscience & Mental Health Program, Hospital for Sick Children Research Institute, Toronto M5G 0A4, Canada.; Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal H4H 1R3, Canada.; Integrated Program in Neuroscience, McGill University, Montreal H3A 1A1, Canada., Wong J; Centre for Addiction and Mental Health, Toronto M6J 1H4, Canada., Crosbie J; Department of Psychiatry, University of Toronto, Toronto M5T 1R8, Canada.; Psychiatry Research, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Schachar R; Department of Psychiatry, University of Toronto, Toronto M5T 1R8, Canada.; Department of Psychiatry, The Hospital for Sick Children, Toronto M5G 1X8, Canada., Nicolson R; The Children's Health Research Institute and Western University, London N6C 2V5, Canada., Georgiades S; Offord Centre for Child Studies & Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton L8N 3K7, Canada., Kelley E; Department of Psychology, Queen's University, Kingston K7L 3N6, Canada., Ayub M; Department of Psychiatry, Queen's University, Kingston K7L7X3, Canada., Hammill C; Neuroscience & Mental Health Program, Hospital for Sick Children Research Institute, Toronto M5G 0A4, Canada.; Mouse Imaging Centre, Hospital for Sick Children, Toronto M5T 3H7, Canada., Ameis SH; Program in Brain and Mental Health, The Hospital for Sick Children, Toronto M5G 1X8 , Canada.; The Margaret and Wallace McCain Centre for Child, Youth, & Family Mental Health, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto M6J 1H4, Canada.; Department of Psychiatry, University of Toronto, Toronto M5T 1R8, Canada., Taylor MJ; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto M5S 1A8, Canada.; Neuroscience & Mental Health Program, Hospital for Sick Children Research Institute, Toronto M5G 0A4, Canada.; Diagnostic Imaging, The Hospital for Sick Children, Toronto M5G 1X8, Canada.; Department of Medical Imaging, University of Toronto, Toronto M5T 1W7, Canada., Lerch JP; Neuroscience & Mental Health Program, Hospital for Sick Children Research Institute, Toronto M5G 0A4, Canada.; Department of Medical Biophysics, University of Toronto, Toronto M5G 1L7, Canada.; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK., Anagnostou E; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto M4G 1R8, Canada.; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto M5S 1A8, Canada.; Department of Pediatrics, University of Toronto, Toronto M5G 1X8, Canada.; Neuroscience & Mental Health Program, Hospital for Sick Children Research Institute, Toronto M5G 0A4, Canada.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2022 May 30; Vol. 32 (11), pp. 2332-2342.
DOI:	10.1093/cercor/bhab326
Abstrakt:	Shared etiological pathways are suggested in ASD and ADHD given high rates of comorbidity, phenotypic overlap and shared genetic susceptibility. Given the peak of cortical gyrification expansion and emergence of ASD and ADHD symptomology in early development, we investigated gyrification morphology in 539 children and adolescents (6-17 years of age) with ASD (n=197) and ADHD (n=96) compared to typically developing controls (n=246) using the local Gyrification Index (lGI) to provide insight into contributing etiopathological factors in these two disorders. We also examined IQ effects and functional implications of gyrification by exploring the relation between lGI and ASD and ADHD symptomatology beyond diagnosis. General Linear Models yielded no group differences in lGI, and across groups, we identified an age-related decrease of lGI and greater lGI in females compared to males. No diagnosis-by-age interactions were found. Accounting for IQ variability in the model (n=484) yielded similar results. No significant associations were found between lGI and social communication deficits, repetitive and restricted behaviours, inattention or adaptive functioning. By examining both disorders and controls using shared methodology, we found no evidence of atypicality in gyrification as measured by the lGI in these conditions. (© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.)
Databáze:	MEDLINE
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