Relationship Between Time-Weighted Head Impact Exposure on Directional Changes in Diffusion Imaging in Youth Football Players.

Autor: Puvvada SK; Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC, USA., Davenport EM; Department of Radiology, University of Texas Southwestern, Dallas, TX, USA., Holcomb JM; Department of Radiology, University of Texas Southwestern, Dallas, TX, USA., Miller LE; Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC, USA., Whitlow CT; Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Powers AK; Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, NC, USA., Maldjian JA; Department of Radiology, University of Texas Southwestern, Dallas, TX, USA., Stitzel JD; Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC, USA., Urban JE; Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC, USA. jurban@wakehealth.edu.
Jazyk: angličtina
Zdroj: Annals of biomedical engineering [Ann Biomed Eng] 2021 Oct; Vol. 49 (10), pp. 2852-2862. Date of Electronic Publication: 2021 Sep 21.
DOI: 10.1007/s10439-021-02862-4
Abstrakt: Approximately 3.5 million youth and adolescents in the US play football, a sport with one of the highest rates of concussion. Repeated subconcussive head impact exposure (HIE) may lead to negative neurological sequelae. To understand HIE as an independent predictive variable, quantitative cumulative kinematic metrics have been developed to capture the volume (i.e., number), severity (i.e., magnitude), and frequency (i.e., time-weighting by the interval between head impacts). In this study, time-weighted cumulative HIE metrics were compared with directional changes in diffusion tensor imaging (DTI) metrics. Changes in DTI conducted on a per-season, per-player basis were assessed as a dependent variable. Directional changes were defined separately as increases and decreases in the number of abnormal voxels relative to non-contact sport controls. Biomechanical and imaging data from 117 athletes (average age 11.9 ± 1.0 years) enrolled in this study was analyzed. Cumulative HIE metrics were more strongly correlated with increases in abnormal voxels than decreases in abnormal voxels. Additionally, across DTI sub-measures, increases and decreases in mean diffusivity (MD) had the strongest relationships with HIE metrics (increases in MD: average R 2 = 0.1753, average p = 0.0002; decreases in MD: average R 2 = 0.0997, average p = 0.0073). This encourages further investigation into the physiological phenomena represented by directional changes.
(© 2021. Biomedical Engineering Society.)
Databáze: MEDLINE
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