Hemophagocytic lymphohistiocytosis in adults: A key issue in the COVID-19 era.
| Autor: | Pereira MAM; Faculdade de Medicina, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro, Brazil., da Costa LMM; Faculdade de Medicina, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil., Nascimento SB; General Pathology at Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil., Kang HC; Universidade Federal Fluminense, Departamento de Patologia, Niterói, Rio de Janeiro, Brazil., Gabriel AHD; Universidade Federal Fluminense, Departamento de Medicina Clínica, Niterói, Rio de Janeiro, Brazil.; Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Clinical infection in practice [Clin Infect Pract] 2021 Nov; Vol. 12, pp. 100100. Date of Electronic Publication: 2021 Sep 17. |
| DOI: | 10.1016/j.clinpr.2021.100100 |
| Abstrakt: | Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by persistent activation of the mononuclear phagocytic system, systemic inflammation, and hypercytokinaemia, which can lead to liver failure, "sepsis-like syndrome" and ultimately, to multiple organ failure and death. These disorders can be divided into primary and secondary (or reactive), the first, also known as familial HLH, is a genetic condition of childhood, which affects the function of TCD8 and NK cells, and usually presents in the first year of life. The secondary HLH affects mainly adults and adolescents and, it's more related to dysregulation of the immune system. In face of the COVID-19 pandemic and several reports of HLH by SARS-CoV-2, it is necessary to discuss the pathophysiology of HLH in adults more clearly. Thus, we present, for the first time, a didactic approach using illustrations and tables, compiling the most recent and relevant information to better understand this entity. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 Published by Elsevier Ltd on behalf of British Infection Association.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|