Natural Killer Cell Enteropathy With Extraintestinal Involvement: Presenting as Symptomatic Anemia.

Autor: Panigrahi MK; Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, India., Patra S; Department of Pathology, All India Institute of Medical Sciences, Bhubaneswar, India., Kumar C; Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, India., Nayak HK; Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, India., Ayyanar P; Department of Pathology, All India Institute of Medical Sciences, Bhubaneswar, India., Bhat SJ; Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, India., Chouhan MI; Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, India., Samal SC; Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, India.
Jazyk: angličtina
Zdroj: ACG case reports journal [ACG Case Rep J] 2021 May 19; Vol. 8 (5), pp. e00599. Date of Electronic Publication: 2021 May 19 (Print Publication: 2021).
DOI: 10.14309/crj.0000000000000599
Abstrakt: Natural killer (NK) cell enteropathy is a newly described disease entity with benign behavior and an indolent clinical course, characterized by the atypical proliferation of NK cells throughout the gastrointestinal tract. The exact etiology is unknown. It closely mimics NK/T-cell lymphoma. We describe this atypical entity in a young adult man presenting with vague upper gastrointestinal symptoms and anemia requiring blood transfusion. The response to budesonide therapy points toward a possible low-grade autoimmune process. Considering the benign behavior and self-limiting course, recognizing this entity is essential to avoid over the investigation and aggressive, inappropriate therapy.
(© 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.)
Databáze: MEDLINE
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