Lipid-based therapies against SARS-CoV-2 infection.

Autor: Alketbi EH; Department of Applied Biology, College of Sciences, University of Sharjah, Sharjah, United Arab Emirates., Hamdy R; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.; Faculty of Pharmacy, Zagazig University, Zagazig, Egypt., El-Kabalawy A; Faculty of Medicine, Tanta University, Tanta, Egypt., Juric V; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria., Pignitter M; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria., A Mosa K; Department of Applied Biology, College of Sciences, University of Sharjah, Sharjah, United Arab Emirates.; Research Institute of Science and Engineering, University of Sharjah, Sharjah, United Arab Emirates.; Department of Biotechnology, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt., Almehdi AM; Department of Chemistry, College of Sciences, University of Sharjah, Sharjah, United Arab Emirates., El-Keblawy AA; Department of Applied Biology, College of Sciences, University of Sharjah, Sharjah, United Arab Emirates.; Research Institute of Science and Engineering, University of Sharjah, Sharjah, United Arab Emirates., Soliman SSM; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.; Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.; Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.
Jazyk: angličtina
Zdroj: Reviews in medical virology [Rev Med Virol] 2021 Sep; Vol. 31 (5), pp. 1-13. Date of Electronic Publication: 2021 Jan 13.
DOI: 10.1002/rmv.2214
Abstrakt: Viruses have evolved to manipulate host lipid metabolism to benefit their replication cycle. Enveloped viruses, including coronaviruses, use host lipids in various stages of the viral life cycle, particularly in the formation of replication compartments and envelopes. Host lipids are utilised by the virus in receptor binding, viral fusion and entry, as well as viral replication. Association of dyslipidaemia with the pathological development of Covid-19 raises the possibility that exploitation of host lipid metabolism might have therapeutic benefit against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this review, promising host lipid targets are discussed along with potential inhibitors. In addition, specific host lipids are involved in the inflammatory responses due to viral infection, so lipid supplementation represents another potential strategy to counteract the severity of viral infection. Furthermore, switching the lipid metabolism through a ketogenic diet is another potential way of limiting the effects of viral infection. Taken together, restricting the access of host lipids to the virus, either by using lipid inhibitors or supplementation with exogenous lipids, might significantly limit SARS-CoV-2 infection and/or severity.
(© 2020 John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: