Inconsistencies in fertility preservation for young people with cancer in the UK.

Autor:	Newton HL; University of Leeds Leeds Institute of Cardiovascular and Metabolic Medicine, Leeds, UK.; Obstetrics & Gynaecology, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Picton HM; University of Leeds Leeds Institute of Cardiovascular and Metabolic Medicine, Leeds, UK., Friend AJ; Leeds Institute of Medical Research, University of Leeds, Leeds, UK.; Paediatric and Adolescent Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Hayden CM; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Brougham M; Department of Haematology and Oncology, Royal Hospital for Sick Children, Edinburgh, UK., Cox R; Paediatric Oncology, Bristol Royal Hospital for Children, Bristol, UK., Grandage V; Haematology, University College Hospital, London, UK., Kwok-Williams M; Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Lane S; Paediatric Oncology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Mitchell RT; MRC Centrre for Reproductive Health, University of Edinburgh, Edinburgh, UK.; Department of Diabetes and Endocrinology, Royal Hospital for Sick Children, Edinburgh, UK., Skinner R; Paediatric Haematology, Great North Children's Hospital, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, University of Newcastle upon Tyne, Newcastle upon Tyne, UK., Wallace WH; The University of Edinburgh MRC Centre for Reproductive Health, Edinburgh, UK.; Royal Hospital for Sick Children, Edinburgh, UK., Yeomanson D; Paediatric Oncology, Sheffield Children's Hospital, Sheffield, UK., Glaser AW; Leeds Institute of Medical Research, University of Leeds, Leeds, UK a.glaser@leeds.ac.uk.; Paediatric and Adolescent Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Jazyk:	angličtina
Zdroj:	Archives of disease in childhood [Arch Dis Child] 2022 Mar; Vol. 107 (3), pp. 265-270. Date of Electronic Publication: 2021 Sep 20.
DOI:	10.1136/archdischild-2021-321873
Abstrakt:	Objective: To assess the utilisation of and funding structure for fertility preservation for children diagnosed with cancer in the UK. Design: Survey of paediatric oncologists/haematologists. Questionnaires were sent electronically with reminder notifications to non-responders. Setting: UK Paediatric Oncology Principal Treatment Centres (PTCs). Participants: Paediatric oncologists/haematologists with an interest in the effects of treatment on fertility representing the 20 PTCs across the UK. Main Outcome Measures: Referral practices, sources and length of funding for storage of gametes or gonadal tissue for children diagnosed with cancer in the preceding 12 months. Results: Responses were received from 18 PTCs (90%) with responses to 98.3% of questions. All centres had referred patients for fertility preservation: ovarian tissue collection/storage 100% (n=18 centres), sperm banking 100% (n=17; one centre was excluded due to the age range of their patients), testicular tissue storage 83% (n=15), mature oocyte collection 35% (n=6; one centre was excluded due to the age range of their patients). All centres with knowledge of their funding source reported sperm cryopreservation was NHS funded. Only 60% (n=9) centres reported the same for mature oocyte storage. Of the centres aware of their funding source, half reported that ovarian and testicular tissue storage was funded by charitable sources; this increased in England compared with the rest of the UK. Conclusions: Inequality exists in provision of fertility preservation for children with cancer across the UK. There is lack of formalised government funding to support international guidelines, with resultant geographical variation in care. Centralised funding of fertility preservation for children and young adults is needed alongside establishment of a national advisory panel to support all PTCs. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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