Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia.

Autor: Daix T; Inserm CIC 1435, Dupuytren Teaching Hospital, 87000, Limoges, France.; UMR 1092, Faculty of Medicine, University of Limoges, 87000, Limoges, France.; Réanimation Polyvalente, CHU Dupuytren, 2 Avenue Martin-Luther King, 87042, Limoges, France., Jeannet R; Inserm CIC 1435, Dupuytren Teaching Hospital, 87000, Limoges, France.; UMR CNRS 7276, INSERM 1262, Faculty of Medicine, University of Limoges, 87000, Limoges, France., Hernandez Padilla AC; Inserm CIC 1435, Dupuytren Teaching Hospital, 87000, Limoges, France.; UMR 1092, Faculty of Medicine, University of Limoges, 87000, Limoges, France., Vignon P; Inserm CIC 1435, Dupuytren Teaching Hospital, 87000, Limoges, France.; UMR 1092, Faculty of Medicine, University of Limoges, 87000, Limoges, France.; Réanimation Polyvalente, CHU Dupuytren, 2 Avenue Martin-Luther King, 87042, Limoges, France., Feuillard J; UMR CNRS 7276, INSERM 1262, Faculty of Medicine, University of Limoges, 87000, Limoges, France.; Hematology Laboratory, Dupuytren Teaching Hospital, 87000, Limoges, France., François B; Inserm CIC 1435, Dupuytren Teaching Hospital, 87000, Limoges, France. b.francois@unilim.fr.; UMR 1092, Faculty of Medicine, University of Limoges, 87000, Limoges, France. b.francois@unilim.fr.; Réanimation Polyvalente, CHU Dupuytren, 2 Avenue Martin-Luther King, 87042, Limoges, France. b.francois@unilim.fr.
Jazyk: angličtina
Zdroj: Journal of intensive care [J Intensive Care] 2021 Sep 20; Vol. 9 (1), pp. 58. Date of Electronic Publication: 2021 Sep 20.
DOI: 10.1186/s40560-021-00575-3
Abstrakt: During COVID-19, immature granulocyte (IG) concentration is heterogeneous with higher concentrations than those found in bacterial sepsis. We investigated the relationship between IG levels at ICU admission and on days 7 (± 2) and 15 (± 2) and associated pulmonary bacterial infections in intensive care unit (ICU) patients hospitalized for an acute respiratory distress syndrome (ARDS) related to SARS-CoV-2. Patients with associated pulmonary bacterial infection had a peak of IGs. IG thresholds of 18% or 2 G/L allowed discriminating patients with ventilator associated pneumonia with 100% sensitivity and specificity. Our study supports that IGs could help identifying pulmonary bacterial infections in this population.
(© 2021. The Author(s).)
Databáze: MEDLINE
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