Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants.

Autor:	Neuman BW; Global Health Research Complex, Division of Research, Texas A&M University, College Station, Texas.; College of Science, College Station, Texas., Brashear WA; Texas A&M Institute for Genome Sciences and Society, College Station, Texas., Brun M; Texas A&M AgriLife Research, College Station, Texas., Chaki SP; Global Health Research Complex, Division of Research, Texas A&M University, College Station, Texas., Fischer RSB; School of Public Health, Texas A&M University, College Station, Texas., Guidry SJ; Global Health Research Complex, Division of Research, Texas A&M University, College Station, Texas., Hill JE; Texas A&M AgriLife Research, College Station, Texas., Hillhouse AE; Texas A&M Institute for Genome Sciences and Society, College Station, Texas.; College of Medicine, College Station, Texas., Johnson CD; Texas A&M AgriLife Research, College Station, Texas., Kahl-McDonagh MM; Global Health Research Complex, Division of Research, Texas A&M University, College Station, Texas., Metz RP; Texas A&M AgriLife Research, College Station, Texas., Rice-Ficht AC; Global Health Research Complex, Division of Research, Texas A&M University, College Station, Texas.; College of Medicine, College Station, Texas., Shuford JA; Texas Department of State Health Services, State Epidemiologist, Austin, Texas., Skaggs TA; Student Health Services, Texas A&M University, College Station, Texas., Stull MA; Texas A&M AgriLife Research, College Station, Texas., Threadgill DW; Texas A&M Institute for Genome Sciences and Society, College Station, Texas.; College of Medicine, College Station, Texas., Akpalu Y; Brazos County Health Department, Epidemiology, College Station, Texas., Zuelke K; Global Health Research Complex, Division of Research, Texas A&M University, College Station, Texas.
Jazyk:	angličtina
Zdroj:	The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2021 Sep 20; Vol. 105 (5), pp. 1227-1229. Date of Electronic Publication: 2021 Sep 20.
DOI:	10.4269/ajtmh.21-0542
Abstrakt:	To better understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage distribution in a college campus population, we carried out viral genome surveillance over a 7-week period from January to March 2021. Among the sequences were three novel viral variants: BV-1 with a B.1.1.7/20I genetic background and an additional spike mutation Q493R, associated with a mild but longer-than-usual COVID-19 case in a college-age person, BV-2 with a T478K mutation on a 20B genetic background, and BV-3, an apparent recombinant lineage. This work highlights the potential of an undervaccinated younger population as a reservoir for the spread and generation of novel variants. This also demonstrates the value of whole genome sequencing as a routine disease surveillance tool.
Databáze:	MEDLINE
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