Neural mapping of anhedonia across psychiatric diagnoses: A transdiagnostic neuroimaging analysis.

Autor:	Schaub AC; University of Basel, Department of Psychiatry (UPK), Basel, Switzerland., Kirschner M; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland., Schweinfurth N; University of Basel, Department of Psychiatry (UPK), Basel, Switzerland., Mählmann L; University of Basel, Department of Psychiatry (UPK), Basel, Switzerland., Kettelhack C; University of Basel, Department of Psychiatry (UPK), Basel, Switzerland., Engeli EE; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland., Doll JPK; University of Basel, Department of Psychiatry (UPK), Basel, Switzerland., Borgwardt S; University of Basel, Department of Psychiatry (UPK), Basel, Switzerland; Department of Psychiatry and Psychotherapy, University of Lübeck, Germany., Lang UE; University of Basel, Department of Psychiatry (UPK), Basel, Switzerland., Kaiser S; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland; Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Switzerland., Walter M; University of Basel, Department of Psychiatry (UPK), Basel, Switzerland., Herdener M; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland., Wrege J; University of Basel, Department of Psychiatry (UPK), Basel, Switzerland., Schmidt A; University of Basel, Department of Psychiatry (UPK), Basel, Switzerland. Electronic address: andre.schmidt@unibas.ch.
Jazyk:	angličtina
Zdroj:	NeuroImage. Clinical [Neuroimage Clin] 2021; Vol. 32, pp. 102825. Date of Electronic Publication: 2021 Sep 16.
DOI:	10.1016/j.nicl.2021.102825
Abstrakt:	Anhedonia has been associated with abnormal reward-related striatal dopamine functioning in patients with different psychiatric disorders. Here, we tested whether anhedonia expression mapped onto striatal volume across several psychiatric diagnoses. T1-weighted images from 313 participants including 89 healthy controls (HC), 22 patients with opioid use disorder (OUD), 50 patients with major depressive disorder (MDD), 45 patients with borderline personality disorder (BPD), 49 patients with first-episode psychosis (FEP), 43 patients with cocaine use disorder (CUD) and 15 patients with schizophrenia (SZ) were included. Anhedonia was assessed with subscores of the Beck Depression Inventory (BDI) and/or the Scale for the Assessment of Negative Symptoms (SANS). Voxel-based morphometry (VBM) was conducted for identifying dimensional symptom-structure associations using region of interest (ROI, dorsal and ventral striatum) and whole-brain analyses, as well as for group comparisons of striatal volume. ROI analyses revealed significant negative relationships between putamen volume and BDI and SANS anhedonia scores across OUD, MDD, BPD, CUD and SZ patients (n = 175) and MDD, FEP and SZ patients (n = 114), respectively. Whole-brain VBM analyses confirmed these associations and further showed negative relationships between anhedonia severity and volume of the bilateral cerebellum. There were group differences in right accumbens volume, which however were not related to anhedonia expression across the different diagnoses. Our findings indicate volumetric abnormalities in the putamen and cerebellum as a common neural substrate of anhedonia severity that cut across psychiatric entities. (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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