CHOROIDAL IMAGING BIOMARKERS TO PREDICT HIGHLY RESPONSIVE AND RESISTANT CASES TREATED WITH STANDARDIZED ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR REGIMEN IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.

Autor:	Jhingan M; Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, Louisiana Jolla, California.; Vitreoretinal Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India., Cavichini M; Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, Louisiana Jolla, California.; Departamento de Oftalmologia, Faculdade de Medicina do ABC, Santo Andre, Brasil., Amador M; Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, Louisiana Jolla, California.; Escuela Superior de Oftalmologia, Instituto Barraquer de America, Bogota, Colombia., Dans K; Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, Louisiana Jolla, California., Bartsch DU; Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, Louisiana Jolla, California., Cheng L; Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, Louisiana Jolla, California., Chhablani J; University of Pittsburgh, UPMC Eye Center, Pittsburgh, Pennsylvania., Freeman WR; Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, Louisiana Jolla, California.
Jazyk:	angličtina
Zdroj:	Retina (Philadelphia, Pa.) [Retina] 2021 Oct 01; Vol. 41 (10), pp. 2115-2121.
DOI:	10.1097/IAE.0000000000003156
Abstrakt:	Purpose: To determine structural predictors of treatment response in neovascular age-related macular degeneration analyzing optical coherence tomography (OCT)-related biomarkers. Methods: A retrospective review of patients undergoing treatment for neovascular age-related macular degeneration at a tertiary institute was performed at presentation. High-intensity regimen included eyes on long-term anti-vascular endothelial growth factor treatment with the inability to extend beyond a month without a relapse and needed double the dose of medication (n = 25). Low-intensity regimen had eyes that went into long-term remission after at least three injections and remained dry for more than a year until the last visit (n = 20). Multimodal imaging including fluorescein angiogram, OCT, and comprehensive ocular evaluation were done. Choroidal vascularity index, total choroidal area, luminal area, subfoveal choroidal thickness, choriocapillaris thickness and Haller and Sattler layer thickness were analyzed for statistical significance. Results: The groups had no significant difference at baseline in age, gender, incidence of reticular pseudodrusen, polypoidal choroidal vasculopathy feature on OCT, type of choroidal neovascular membrane, and geographic atrophy. Multinomial logistic regression revealed that thicker subfoveal choroidal thickness and larger total choroidal area were the significant predictors of poor response to anti-vascular endothelial growth factor treatment (E = 0.02; P = 0.02; E = 1.82; P = 0.0075). Conclusion: Thicker subfoveal choroidal thickness and higher total choroidal area are useful variables to predict a poor treatment response.
Databáze:	MEDLINE
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