Effect of Nitinol on Metabolic and Coagulation Activity of Endothelial Cells Culture.

Autor: Kalinin RE; Ryazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia., Suchkov IA; Ryazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia., Mzhavanadze ND; Ryazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia. nina_mzhavanadze@mail.ru., Korotkova NV; Ryazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia., Zhurina ON; Ryazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia., Povarov VO; Ryazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia., Surov IY; Ryazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia., Bozhenova AD; Ryazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia., Strelnikova EA; Ryazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2021 Aug; Vol. 171 (4), pp. 480-482. Date of Electronic Publication: 2021 Sep 20.
DOI: 10.1007/s10517-021-05255-8
Abstrakt: We studied the effect of nitinol, the most prevalent material for endovascular stents, on metabolic and coagulation activity of a primary culture of human umbilical vein endothelial cells (HUVEC). Metabolic activity was evaluated using MTS-test and by the level of stable NO metabolites in the conditioned medium, coagulation activity was assessed by activity of von Willebrand factor (vWF) and levels of plasminogen activator inhibitor-1 (PAI-1) and soluble endothelial protein C receptors (sEPCR). Exposure to nitinol reduced metabolic activity of the cell culture by 11.1% in comparison with the control (p<0.001). Although absolute activity of vWF and absolute level of sEPCR were elevated, incubation with nitinol did not lead to a statistically significant elevation of these parameters in comparison with the control, which can indicate the absence of substantial hypercoagulation effects of nitinol.
(© 2021. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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