All You Need Is Evidence: What We Know About Pneumonia in Children With Neuromuscular Diseases.

Autor:	Cherchi C; Pediatric Pulmonology and Respiratory Intermediate Care Unit, Sleep and Long Term Ventilation Unit, Academic Department of Pediatrics (DPUO), Pediatric Hospital 'Bambino Gesù' Research Institute, Rome, Italy.; Rare Diseases and Medical Genetics Unit, Bambino Gesù Children Hospital (IRCCS), Rome, Italy., Chiarini Testa MB; Pediatric Pulmonology and Respiratory Intermediate Care Unit, Sleep and Long Term Ventilation Unit, Academic Department of Pediatrics (DPUO), Pediatric Hospital 'Bambino Gesù' Research Institute, Rome, Italy.; Rare Diseases and Medical Genetics Unit, Bambino Gesù Children Hospital (IRCCS), Rome, Italy., Deriu D; Department of Pediatrics, University of Rome Tor Vergata, Rome, Italy., Schiavino A; Pediatric Pulmonology and Respiratory Intermediate Care Unit, Sleep and Long Term Ventilation Unit, Academic Department of Pediatrics (DPUO), Pediatric Hospital 'Bambino Gesù' Research Institute, Rome, Italy.; Rare Diseases and Medical Genetics Unit, Bambino Gesù Children Hospital (IRCCS), Rome, Italy., Petreschi F; Pediatric Pulmonology and Respiratory Intermediate Care Unit, Sleep and Long Term Ventilation Unit, Academic Department of Pediatrics (DPUO), Pediatric Hospital 'Bambino Gesù' Research Institute, Rome, Italy.; Rare Diseases and Medical Genetics Unit, Bambino Gesù Children Hospital (IRCCS), Rome, Italy., Ullmann N; Pediatric Pulmonology and Respiratory Intermediate Care Unit, Sleep and Long Term Ventilation Unit, Academic Department of Pediatrics (DPUO), Pediatric Hospital 'Bambino Gesù' Research Institute, Rome, Italy.; Rare Diseases and Medical Genetics Unit, Bambino Gesù Children Hospital (IRCCS), Rome, Italy., Paglietti MG; Pediatric Pulmonology and Respiratory Intermediate Care Unit, Sleep and Long Term Ventilation Unit, Academic Department of Pediatrics (DPUO), Pediatric Hospital 'Bambino Gesù' Research Institute, Rome, Italy.; Rare Diseases and Medical Genetics Unit, Bambino Gesù Children Hospital (IRCCS), Rome, Italy., Cutrera R; Pediatric Pulmonology and Respiratory Intermediate Care Unit, Sleep and Long Term Ventilation Unit, Academic Department of Pediatrics (DPUO), Pediatric Hospital 'Bambino Gesù' Research Institute, Rome, Italy.; Rare Diseases and Medical Genetics Unit, Bambino Gesù Children Hospital (IRCCS), Rome, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2021 Sep 01; Vol. 9, pp. 625751. Date of Electronic Publication: 2021 Sep 01 (Print Publication: 2021).
DOI:	10.3389/fped.2021.625751
Abstrakt:	Neuromuscular diseases may involve all major respiratory muscles groups including inspiratory, expiratory, and bulbar muscles. Respiratory complications are the major cause of morbidity and mortality. Pneumonia represents a frequent cause of morbidity in children with neuromuscular disease. The aim of this review is to collect knowledge about pneumonia in children with neuromuscular diseases. Pneumonia usually follows viral respiratory infections of the upper respiratory tract, due to the combination of an increased amount of nasal and oral secretions and an impairment of the cough efficiency and of the clearance of secretions due to the muscle weakness, further compromised by the infection itself. The accumulation of bronchial secretions leads to atelectasis and promote bacterial infection. Moreover, dysfunction of swallowing mechanism exposes these children to the risk of developing aspiration pneumonia. However, etiology of viral and bacterial respiratory infection in these patients is still poorly studied. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Cherchi, Chiarini Testa, Deriu, Schiavino, Petreschi, Ullmann, Paglietti and Cutrera.)
Databáze:	MEDLINE
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