Adipokines and C-reactive protein as indicators of MetS presence in obese Greek children: The Healthy Growth Study.

Autor:	Vassilopoulou E; Department of Nutritional Sciences and Dietetics, International Hellenic University, Thessaloniki, Greece., Giannopoulou E; Department of Nutritional Sciences and Dietetics, International Hellenic University, Thessaloniki, Greece., Theodosiou A; School of Physical Education and Sports Science, Aristotle University of Thessaloniki, Greece., Karaglani E; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 El Venizelou Avenue, Kallithea, 17671, Athens, Greece., Manios Y; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 El Venizelou Avenue, Kallithea, 17671, Athens, Greece.; Institute of Agri-food and Life Sciences, Hellenic Mediterranean University Research Centre, 71410 Heraklion, Greece., Moschonis G; Department of Dietetics, Nutrition and Sport, School of Allied Health, Human Services and Sport, La Trobe University, Victoria, 3086, Australia.
Jazyk:	angličtina
Zdroj:	Toxicology reports [Toxicol Rep] 2021 Aug 30; Vol. 8, pp. 1645-1650. Date of Electronic Publication: 2021 Aug 30 (Print Publication: 2021).
DOI:	10.1016/j.toxrep.2021.08.004
Abstrakt:	Background: Metabolic syndrome (MetS) occurs in a proportion of overweight and obese children and increases their future risk of serious health complications, even in adolescence and young adulthood. We aimed to explore the role of certain adipokines and inflammatory markers in identifying children with MetS. Methods: This study is a secondary analysis of data coming from the Healthy Growth Study, a cross-sectional study conducted with schoolchildren in Greece. The present study included data from a representative sample of 1376 schoolchildren (mean age: 11.19 ± 0.66 years), recruited from 77 primary schools in four large regions in Greece. Anthropometric, clinical and biochemical data were recorded. Children's body weight status and the presence of MetS were determined and their correlation with the serum levels of leptin, adiponectin and C-reactive protein (CRP) was explored. Results: The prevalence of the MetS was 21.7 % and 3.7 % in obese and overweight children, respectively. The balance of adipokines was disturbed in obesity, as the serum level of adiponectin decreased as body weight increased, while the serum level of leptin increased. The serum level of the inflammatory marker CRP increased significantly as body weight increased. Discriminant analysis showed that these factors could distinguish the children with MetS as compared to children with no MetS. Conclusions: In the under study Mediterranean childhood population, monitoring of the levels of adipokines and CRP could identify the overweight and obese children with MetS. Appropriate individualized dietary and lifestyle interventions can be applied in these children to prevent health complications associated with MetS. Competing Interests: The authors declare no conflict of interest. (© 2021 Published by Elsevier B.V.)
Databáze:	MEDLINE
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