Acute Impacts of Different Types of Exercise on Circulating α-Klotho Protein Levels.

Autor:	Iturriaga T; Faculty of Physical Activity, Sport Sciences and Physiotherapy, Universidad Europea de Madrid, Madrid, Spain., Yvert T; Faculty of Physical Activity, Sport Sciences and Physiotherapy, Universidad Europea de Madrid, Madrid, Spain., Sanchez-Lorente IM; Faculty of Physical Activity, Sport Sciences and Physiotherapy, Universidad Europea de Madrid, Madrid, Spain., Diez-Vega I; Faculty of Physical Activity, Sport Sciences and Physiotherapy, Universidad Europea de Madrid, Madrid, Spain.; Departamento de Enfermería y Fisioterapia, Facultad de Ciencias de la salud, Universidad de Leon, Ponferrada, Spain., Fernandez-Elias VE; Faculty of Physical Activity, Sport Sciences and Physiotherapy, Universidad Europea de Madrid, Madrid, Spain., Sanchez-Barroso L; Facultad de Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, Madrid, Spain.; Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Madrid, Spain., Dominguez-Balmaseda D; Faculty of Physical Activity, Sport Sciences and Physiotherapy, Universidad Europea de Madrid, Madrid, Spain., Larrosa M; Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Madrid, Spain., Perez-Ruiz M; Faculty of Physical Activity, Sport Sciences and Physiotherapy, Universidad Europea de Madrid, Madrid, Spain.; Servicio de Medicina Física y Rehabilitación, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain., Santiago C; Faculty of Physical Activity, Sport Sciences and Physiotherapy, Universidad Europea de Madrid, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2021 Sep 01; Vol. 12, pp. 716473. Date of Electronic Publication: 2021 Sep 01 (Print Publication: 2021).
DOI:	10.3389/fphys.2021.716473
Abstrakt:	Introduction: Elevated plasma α-klotho (αKl) protects against several ageing phenotypes and has been proposed as a biomarker of a good prognosis for different diseases. The beneficial health effects of elevated plasma levels of soluble αKl (SαKl) have been likened to the positive effects of exercise on ageing and chronic disease progression. It has also been established that molecular responses and adaptations differ according to exercise dose. The aim of this study is to compare the acute SαKl response to different exercise interventions, cardiorespiratory, and strength exercise in healthy, physically active men and to examine the behavior of SαKl 72h after acute strength exercise. Methods: In this quasi-experimental study, plasma SαKl was measured before and after a cardiorespiratory exercise session (CR) in 43 men, and strength exercise session (ST) in 39 men. The behavior of SαKl was also examined 24, 48, and 72h after ST. Results: Significant differences (time×group) were detected in SαKl levels ( p =0.001; d =0.86) between CR and ST. After the ST intervention, SαKl behavior varied significantly ( p =0.009; d =0.663) in that levels dropped between pre- and post-exercises ( p =0.025; d =0.756) and were also significantly higher compared to pre ST values at 24h ( p =0.033; d =0.717) and at 48h ( p =0.015; d =0.827). Conclusions: SαKl levels increased in response to a single bout of cardiorespiratory exercise; while they decreased immediately after strength exercise, levels were elevated after 24h indicating different klotho protein responses to different forms of exercise. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Iturriaga, Yvert, Sanchez-Lorente, Diez-Vega, Fernandez-Elias, Sanchez-Barroso, Dominguez-Balmaseda, Larrosa, Perez-Ruiz and Santiago.)
Databáze:	MEDLINE
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