Disturbances in the intraventricular conduction system in teenagers with type 1 diabetes. A pilot study.

Autor: Zubkiewicz-Kucharska A; Department of Pediatric Endocrinology and Diabetology, Wrocław Medical University, Chałubińskiego Str. 2a, 50-368 Wrocław, Poland. Electronic address: agnieszka.zubkiewicz-kucharska@umed.wroc.pl., Noczyńska A; Department of Pediatric Endocrinology and Diabetology, Wrocław Medical University, Chałubińskiego Str. 2a, 50-368 Wrocław, Poland., Sobieszczańska M; Department and Clinic of Geriatrics, Wrocław Medical University, Skłodowskiej-Curie Str. 66, 50-369 Wrocław, Poland., Poręba M; Department of Pathophysiology, Wrocław Medical University, Marcinkowskiego Str. 1, 50-368 Wrocław, Poland., Chrzanowska J; Department of Pediatric Endocrinology and Diabetology, Wrocław Medical University, Chałubińskiego Str. 2a, 50-368 Wrocław, Poland., Poręba R; Department and Clinic of Internal and Occupational Diseases and Hypertension, Wrocław Medical University, Borowska Str. 213, 50-556 Wrocław, Poland., Seifert M; Department of Pediatric Endocrinology and Diabetology, Wrocław Medical University, Chałubińskiego Str. 2a, 50-368 Wrocław, Poland., Janocha A; Department of Pathophysiology, Wrocław Medical University, Marcinkowskiego Str. 1, 50-368 Wrocław, Poland., Laszki-Szcząchor K; Department of Pathophysiology, Wrocław Medical University, Marcinkowskiego Str. 1, 50-368 Wrocław, Poland.
Jazyk: angličtina
Zdroj: Journal of diabetes and its complications [J Diabetes Complications] 2021 Nov; Vol. 35 (11), pp. 108043. Date of Electronic Publication: 2021 Sep 01.
DOI: 10.1016/j.jdiacomp.2021.108043
Abstrakt: Body Surface Potential Mapping (BSPM) is a multi-electrode synchronous method for examining electrocardiographic records on the patients' body surface that allows the assessment of changes in the heart conduction system. The aim of the study was to visualize and evaluate changes in the intraventricular system in adolescents with T1D.
Patients and Methods: Inclusion criteria: age > 12 years, T1D duration >3 years, HbA1c >8%.
Exclusion Criteria: diagnosis of autonomic neuropathy, heart structural defects, heart failure. BSPM data were processed into map plotting to illustrate differences in ventricular activation time (VAT, isochron lines).
Results: 33 teenagers (20 boys), mean age 15.0 ± 2.1 years, T1D from 6.8 ± 4.1 years were included. Mean HbA1c was 9.6 ± 2.0%. In the standard ECG recording abnormalities were not present. The distribution of isolines on the group-mean map plotted for T1D patients only initially resembles the course of isolines on the group-map for normal subjects (N = 30), in whom the electrical impulse stimulating the heart ventricles passes through the atrio-ventricular node, then symmetrically excites the branches of His bundle and finally the Purkinje fibers. In T1D patients, after proper onset of intraventricular stimulation, the isolines reflecting the both ventricles reach higher time values, which indicates problems in the propagation of the ventricular depolarization.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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