Distinct genetic architectures underlie divergent thorax, leg, and wing pigmentation between Drosophila elegans and D. gunungcola.

Autor: Massey JH; Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, USA.; Janelia Research Campus of the Howard Hughes Medical Institute, Ashburn, VA, USA., Li J; Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, USA.; Institute of Evolution and Ecology, School of Life Sciences, Central China Normal University, Wuhan, China., Stern DL; Janelia Research Campus of the Howard Hughes Medical Institute, Ashburn, VA, USA., Wittkopp PJ; Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, USA. wittkopp@umich.edu.; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. wittkopp@umich.edu.
Jazyk: angličtina
Zdroj: Heredity [Heredity (Edinb)] 2021 Nov; Vol. 127 (5), pp. 467-474. Date of Electronic Publication: 2021 Sep 18.
DOI: 10.1038/s41437-021-00467-0
Abstrakt: Pigmentation divergence between Drosophila species has emerged as a model trait for studying the genetic basis of phenotypic evolution, with genetic changes contributing to pigmentation differences often mapping to genes in the pigment synthesis pathway and their regulators. These studies of Drosophila pigmentation have tended to focus on pigmentation changes in one body part for a particular pair of species, but changes in pigmentation are often observed in multiple body parts between the same pair of species. The similarities and differences of genetic changes responsible for divergent pigmentation in different body parts of the same species thus remain largely unknown. Here we compare the genetic basis of pigmentation divergence between Drosophila elegans and D. gunungcola in the wing, legs, and thorax. Prior work has shown that regions of the genome containing the pigmentation genes yellow and ebony influence the size of divergent male-specific wing spots between these two species. We find that these same two regions of the genome underlie differences in leg and thorax pigmentation; however, divergent alleles in these regions show differences in allelic dominance and epistasis among the three body parts. These complex patterns of inheritance can be explained by a model of evolution involving tissue-specific changes in the expression of Yellow and Ebony between D. elegans and D. gunungcola.
(© 2021. The Author(s), under exclusive licence to The Genetics Society.)
Databáze: MEDLINE
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