STRUCTURE OF THE KNEE ARTICULAR CARTILAGE AFTER THE FEMUR AND TIBIA EXTRA-ARTICULAR INJURY.

Autor:	Tkachenko AS; SUMY STATE UNIVERSITY, SUMY, UKRAINE., Maksymova OS; SUMY STATE UNIVERSITY, SUMY, UKRAINE., Korenkov OV; SUMY STATE UNIVERSITY, SUMY, UKRAINE., Voznyi AP; SUMY STATE UNIVERSITY, SUMY, UKRAINE., Tkach GF; SUMY STATE UNIVERSITY, SUMY, UKRAINE.
Jazyk:	angličtina
Zdroj:	Wiadomosci lekarskie (Warsaw, Poland : 1960) [Wiad Lek] 2021; Vol. 74 (8), pp. 1863-1868.
Abstrakt:	Objective: The aim: To study the microscopic, ultramicroscopic, and histomorphometric features of the knee articular cartilage in rats with an extra-articular injury of the femur and tibia. Patients and Methods: Materials and methods: 60 white laboratory rats divided into three groups (I - control; II - animals with traumatic femur injury; III - animals with traumatic tibia injury) were used for the study. The light microscopy was performed by Olympus BH-2 microscope (Japan), transmission electron microscopy - by JEM-1230 microscope (Japan). SPSS software (version 17.0) was used for mathematical analysis. Results: Results: The more pronounced morphological changes were observed in the articular cartilage of the proximal tibial epiphysis after mechanical tibial injury. The thickness of the articular cartilage was 27.89 % less than in the control. The chondrocyte number in the superficial zone was lower by 8.94 %, intermediate zone - by 14.23 %, and deep zone - by 21.83%, compared to control. Herewith, the histological changes were mostly detected in the intermediate and deep zones of the articular cartilage of both bones. Also, some chondrocytes had deformed nuclei, hypertrophied organelles, numerous inclusions, and residual glycogen granules. Conclusion: Conclusion: The extra-articular mechanical trauma of the lower limb bones leads to pathological changes in the knee articular cartilage. The structural changes include the articular cartilage thickening, the decrease in chondrocyte number, as well as chondrocyte rearrangement due to degenerative-dystrophic processes.
Databáze:	MEDLINE
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