The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages.

Autor:	Martin DP; Institute of Infectious Diseases and Molecular Medicine, Division Of Computational Biology, Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town 7701, South Africa. Electronic address: darrenpatrickmartin@gmail.com., Weaver S; Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, Philadelphia, PA 19122, USA., Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform, School of Laboratory Medicine & Medical Sciences, University of KwaZulu- Natal, Durban 4001, South Africa., San JE; KwaZulu-Natal Research Innovation and Sequencing Platform, School of Laboratory Medicine & Medical Sciences, University of KwaZulu- Natal, Durban 4001, South Africa., Shank SD; Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, Philadelphia, PA 19122, USA., Wilkinson E; KwaZulu-Natal Research Innovation and Sequencing Platform, School of Laboratory Medicine & Medical Sciences, University of KwaZulu- Natal, Durban 4001, South Africa., Lucaci AG; Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, Philadelphia, PA 19122, USA., Giandhari J; KwaZulu-Natal Research Innovation and Sequencing Platform, School of Laboratory Medicine & Medical Sciences, University of KwaZulu- Natal, Durban 4001, South Africa., Naidoo S; KwaZulu-Natal Research Innovation and Sequencing Platform, School of Laboratory Medicine & Medical Sciences, University of KwaZulu- Natal, Durban 4001, South Africa., Pillay Y; KwaZulu-Natal Research Innovation and Sequencing Platform, School of Laboratory Medicine & Medical Sciences, University of KwaZulu- Natal, Durban 4001, South Africa., Singh L; KwaZulu-Natal Research Innovation and Sequencing Platform, School of Laboratory Medicine & Medical Sciences, University of KwaZulu- Natal, Durban 4001, South Africa., Lessells RJ; KwaZulu-Natal Research Innovation and Sequencing Platform, School of Laboratory Medicine & Medical Sciences, University of KwaZulu- Natal, Durban 4001, South Africa., Gupta RK; Clinical Microbiology, University of Cambridge, Cambridge CB2 1TN, UK; Africa Health Research Institute, KwaZulu-Natal 4013, South Africa., Wertheim JO; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA., Nekturenko A; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, State College, PA 16802, USA., Murrell B; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 141 83, Sweden., Harkins GW; South African Medical Research Council Capacity Development Unit, South African National Bioinformatics Institute, University of the Western Cape, Bellville 7635, South Africa., Lemey P; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven 3000, Belgium., MacLean OA; MRC-University of Glasgow Centre for Virus Research, Glasgow 12 8QQ, Scotland, UK., Robertson DL; MRC-University of Glasgow Centre for Virus Research, Glasgow 12 8QQ, Scotland, UK., de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform, School of Laboratory Medicine & Medical Sciences, University of KwaZulu- Natal, Durban 4001, South Africa; Department of Global Health, University of Washington, Seattle, WA 98195-4550, USA. Electronic address: tuliodna@gmail.com., Kosakovsky Pond SL; Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, Philadelphia, PA 19122, USA. Electronic address: spond@temple.edu.
Jazyk:	angličtina
Zdroj:	Cell [Cell] 2021 Sep 30; Vol. 184 (20), pp. 5189-5200.e7. Date of Electronic Publication: 2021 Sep 07.
DOI:	10.1016/j.cell.2021.09.003
Abstrakt:	The independent emergence late in 2020 of the B.1.1.7, B.1.351, and P.1 lineages of SARS-CoV-2 prompted renewed concerns about the evolutionary capacity of this virus to overcome public health interventions and rising population immunity. Here, by examining patterns of synonymous and non-synonymous mutations that have accumulated in SARS-CoV-2 genomes since the pandemic began, we find that the emergence of these three "501Y lineages" coincided with a major global shift in the selective forces acting on various SARS-CoV-2 genes. Following their emergence, the adaptive evolution of 501Y lineage viruses has involved repeated selectively favored convergent mutations at 35 genome sites, mutations we refer to as the 501Y meta-signature. The ongoing convergence of viruses in many other lineages on this meta-signature suggests that it includes multiple mutation combinations capable of promoting the persistence of diverse SARS-CoV-2 lineages in the face of mounting host immune recognition. Competing Interests: Declaration of interests J.O.W. has been funded by Gilead Sciences, LLC (completed) and the CDC (ongoing) via grants and contracts to his institution unrelated to this research. (Copyright © 2021. Published by Elsevier Inc.)
Databáze:	MEDLINE
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