Predicting regression of cervical intraepithelial neoplasia grade 2 in women under 25 years.

Autor: Sykes PH; Department of Obstetrics and Gynaecology, University of Otago, Christchurch, New Zealand; Christchurch Women's Hospital, Canterbury District Health Board, Christchurch, New Zealand. Electronic address: peter.sykes@otago.ac.nz., Simcock BJ; Department of Obstetrics and Gynaecology, University of Otago, Christchurch, New Zealand; Christchurch Women's Hospital, Canterbury District Health Board, Christchurch, New Zealand., Innes CR; Department of Obstetrics and Gynaecology, University of Otago, Christchurch, New Zealand., Harker D; Department of Obstetrics and Gynaecology, University of Otago, Christchurch, New Zealand., Williman JA; Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand., Whitehead M; Department of Pathology, University of Otago, Christchurch, New Zealand; Canterbury Health Laboratories, Christchurch Hospital, Christchurch, New Zealand., van der Griend RA; Canterbury Health Laboratories, Christchurch Hospital, Christchurch, New Zealand., Lawton BA; Centre for Women's Health Research, Victoria University of Wellington, Wellington, New Zealand., Hibma M; Department of Pathology, University of Otago, Dunedin, New Zealand., Fitzgerald P; Southern Community Laboratories, Dunedin, New Zealand., Dudley NM; Women's Health Service, Waikato District Health Board, Hamilton, New Zealand., Petrich S; Gynaecology Services, Southern District Health Board, Dunedin, New Zealand., Eva L; National Women's Health, Auckland District Health Board, Auckland, New Zealand., Bergzoll C; National Women's Health, Auckland District Health Board, Auckland, New Zealand., Kathuria J; Counties Manukau District Health Board, Auckland, New Zealand., McPherson G; Waitemata District Health Board, Auckland, New Zealand., Tristram A; Capital and Coast District Health Board, Wellington, New Zealand., Faherty J; Obstetrics and Gynaecology Services, Southland Hospital, Invercargill, New Zealand., Hardie D; Northland District Health Board, Whangarei, New Zealand., Robertson A; MidCentral District Health Board, Palmerston North, New Zealand., Robertson V; Grey Base Hospital, Greymouth, New Zealand., Pather S; Chris O'Brien Lifehouse, Camperdown, Sydney, Australia; Central Clinical School, University of Sydney, Sydney, Australia., Wrede CD; The Royal Women's Hospital, Melbourne, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia., Gastrell F; Nelson Marlborough District Health Board, Nelson, New Zealand., Fentiman G; Nelson Marlborough District Health Board, Nelson, New Zealand., John M; Bay of Plenty District Health Board, Tauranga, New Zealand., White E; Hawke's Bay District Health Board, Hastings, New Zealand., Parker C; South Canterbury District Health Board, Timaru, New Zealand., Sadler L; National Women's Health, Auckland District Health Board, Auckland, New Zealand; Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand.
Jazyk: angličtina
Zdroj: American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2022 Feb; Vol. 226 (2), pp. 222.e1-222.e13. Date of Electronic Publication: 2021 Sep 14.
DOI: 10.1016/j.ajog.2021.09.009
Abstrakt: Background: A number of retrospective and prospective studies have documented substantial rates of regression in cervical intraepithelial neoplasia grade 2 lesions in young women. Initial observational management of cervical intraepithelial neoplasia grade 2 is increasingly accepted as appropriate for women under 25 years of age with screen-detected abnormalities and is included in a number of clinical guidelines. However, there has been a paucity of large prospective studies on observational management with strict inclusion criteria. A number of important questions remain, specifically regarding the clinical variables that are associated with the risk of progression or persistence of disease. To investigate these factors and to ensure that young women with cervical intraepithelial neoplasia grade 2 undergoing observational management were being managed in a well-monitored and an appropriately informed fashion, we conducted a large, multicenter prospective study on observational management of cervical intraepithelial neoplasia grade 2 in women under 25 years.
Objective: This study aimed to determine the regression rates and clinical, cytologic, and pathologic predictors of regression of cervical intraepithelial neoplasia grade 2 in women under 25 years undergoing observational management over 24 months.
Study Design: This study was a multicenter prospective study on observational management of cervical intraepithelial neoplasia grade 2 (ie, repeat colposcopy, cytology, and cervical biopsy every 6 months) for up to 24 months. A total of 615 consenting women under 25 years with newly-diagnosed, biopsy-proven cervical intraepithelial neoplasia grade 2 were recruited (from 2010 to 2016) through 16 hospital-based colposcopy units in New Zealand and Australia.
Results: At completion, 326 women had confirmed regression, 156 had persistent high-grade cervical intraepithelial neoplasia grade 2 or 3 or adenocarcinoma in situ, and 24 had unconfirmed regression (ie, first regression at the 24-month follow-up). A total of 109 women did not complete the protocol (41 because of delayed follow-up, 41 lost to follow-up, 22 elected treatment, 4 refused a biopsy, and 1 died of an unrelated cause). Confirmed regression was observed in 53% (326 of 615) of all women enrolled in the study and, when missing data were imputed, it was estimated that 64% of women (95% confidence interval, 60%-68%) would have experienced regression. Similarly, lesions regressed in 64% (326 of 506) of women who completed the observational protocol. Based on a multivariable analysis, detection of human papillomavirus 16 in a liquid-based cytology sample at the time of initial colposcopy decreased the chance of regression by 31% (risk ratio, 0.69; 95% confidence interval, 0.56-0.86; P<.001). In addition, at initial colposcopy, low-grade or normal colposcopic impression, later year of diagnosis, low-grade or normal cytology, and being a nonsmoker were all independently associated with an increased chance of regression.
Conclusion: More than half of women under 25 years with cervical intraepithelial neoplasia grade 2 will regress to cervical intraepithelial neoplasia grade 1 or normal within 24 months without destructive treatment. The absence of human papillomavirus 16 is the most important predictor of regression.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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