Action-based organization of a cerebellar module specialized for predictive control of multiple body parts.
| Autor: | Heiney SA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: shane-heiney@uiowa.edu., Wojaczynski GJ; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA., Medina JF; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: jfmedina@bcm.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Neuron [Neuron] 2021 Sep 15; Vol. 109 (18), pp. 2981-2994.e5. |
| DOI: | 10.1016/j.neuron.2021.08.017 |
| Abstrakt: | The role of the cerebellum in predictive motor control and coordination has been thoroughly studied during movements of a single body part. In the real world, however, actions are often more complex. Here, we show that a small area in the rostral anterior interpositus nucleus (rAIN) of the mouse cerebellum is responsible for generating a predictive motor synergy that serves to protect the eye by precisely coordinating muscles of the eyelid, neck, and forelimb. Within the rAIN region, we discovered a new functional category of neurons with unique properties specialized for control of motor synergies. These neurons integrated inhibitory cutaneous inputs from multiple parts of the body, and their activity was correlated with the vigor of the defensive motor synergy on a trial-by-trial basis. We propose that some regions of the cerebellum are organized in poly-somatotopic "action maps" to reduce dimensionality and simplify motor control during ethologically relevant behaviors. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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