The role of glucagon-like peptide 1 (GLP-1) in addictive disorders.

Autor: Klausen MK; Psychiatric Centre Copenhagen, Rigshospitalet, Mental Health Services, Capital Region of Denmark and University Hospital of Copenhagen, Copenhagen, Denmark., Thomsen M; Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen and University Hospital of Copenhagen, Copenhagen, Denmark., Wortwein G; Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen and University Hospital of Copenhagen, Copenhagen, Denmark.; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Fink-Jensen A; Psychiatric Centre Copenhagen, Rigshospitalet, Mental Health Services, Capital Region of Denmark and University Hospital of Copenhagen, Copenhagen, Denmark.; Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen and University Hospital of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: British journal of pharmacology [Br J Pharmacol] 2022 Feb; Vol. 179 (4), pp. 625-641.
DOI: 10.1111/bph.15677
Abstrakt: Drug, alcohol and tobacco use disorders are a global burden affecting millions of people. Despite decades of research, treatment options are sparse or missing, and relapse rates are high. Glucagon-like peptide 1 (GLP-1) is released in the small intestine, promotes blood glucose homeostasis, slows gastric emptying and reduces appetite. GLP-1 receptor agonists approved for treating Type 2 diabetes mellitus and obesity have received attention as a potential anti-addiction treatment. Studies in rodents and non-human primates have demonstrated a reduction in intake of alcohol and drugs of abuse, and clinical trials have been initiated to investigate whether the preclinical findings can be translated to patients. This review will give an overview of current findings and discuss the possible mechanisms of action. We suggest that effects of GLP-1 in alcohol and substance use disorders is mediated centrally, at least partly through dopamine signalling, but precise mechanisms are still to be uncovered. LINKED ARTICLES: This article is part of a themed issue on GLP1 receptor ligands (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.4/issuetoc.
(© 2021 The British Pharmacological Society.)
Databáze: MEDLINE
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