Modified wavelet analysis of ECoG-pattern as promising tool for detection of the blood-brain barrier leakage.

Autor: Runnova A; Saratov State Medical University, B. Kazachaya str. 112, Saratov, 410012, Russia. runnova.ae@staff.sgmu.ru.; Saratov State University, Astrakhanskaya str. 83, Saratov, 410012, Russia. runnova.ae@staff.sgmu.ru., Zhuravlev M; Saratov State Medical University, B. Kazachaya str. 112, Saratov, 410012, Russia.; Saratov State University, Astrakhanskaya str. 83, Saratov, 410012, Russia., Ukolov R; Saratov State Medical University, B. Kazachaya str. 112, Saratov, 410012, Russia.; Saratov State University, Astrakhanskaya str. 83, Saratov, 410012, Russia., Blokhina I; Saratov State University, Astrakhanskaya str. 83, Saratov, 410012, Russia., Dubrovski A; Saratov State University, Astrakhanskaya str. 83, Saratov, 410012, Russia., Lezhnev N; Saratov State University, Astrakhanskaya str. 83, Saratov, 410012, Russia., Sitnikova E; Institute of Higher Nervous Activity and Neurophysiology of RAS, (IHNA&NPh RAS), Butlerova str. 5a, Moscow, 117485, Russia., Saranceva E; Saratov State University, Astrakhanskaya str. 83, Saratov, 410012, Russia., Kiselev A; Saratov State Medical University, B. Kazachaya str. 112, Saratov, 410012, Russia.; National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky per. 10, Moscow, 101953, Russia., Karavaev A; Saratov State Medical University, B. Kazachaya str. 112, Saratov, 410012, Russia.; Saratov State University, Astrakhanskaya str. 83, Saratov, 410012, Russia.; Saratov Branch of the Institute of RadioEngineering and Electronics of Russian Academy of Sciences, Zelyonaya str. 38, Saratov, 410019, Russia., Selskii A; Saratov State University, Astrakhanskaya str. 83, Saratov, 410012, Russia., Semyachkina-Glushkovskaya O; Saratov State University, Astrakhanskaya str. 83, Saratov, 410012, Russia., Penzel T; Saratov State Medical University, B. Kazachaya str. 112, Saratov, 410012, Russia.; Saratov State University, Astrakhanskaya str. 83, Saratov, 410012, Russia.; Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, 10117, Germany., Kurths J; Saratov State University, Astrakhanskaya str. 83, Saratov, 410012, Russia.; Potsdam Institute for Climate Impact Research, Telegrafenberg A31, Potsdam, 14473, Germany.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Sep 16; Vol. 11 (1), pp. 18505. Date of Electronic Publication: 2021 Sep 16.
DOI: 10.1038/s41598-021-97427-9
Abstrakt: A new approach for detection oscillatory patterns and estimation of their dynamics based by a modified CWT skeleton method is presented. The method opens up additional perspectives for the analysis of subtle changes in the oscillatory activity of complex nonstationary signals. The method was applied to analyze unique experimental signals obtained in usual conditions and after the non-invasive increase in the blood-brain barrier (BBB) permeability in 10 male Wistar rats. The results of the wavelet-analysis of electrocorticography (ECoG) recorded in a normal physiological state and after an increase in the BBB permeability of animals demonstrate significant changes between these states during wakefulness of animals and an essential smoothing of these differences during sleep. Sleep is closely related to the processes of observed changes in the BBB permeability.
(© 2021. The Author(s).)
Databáze: MEDLINE
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