Musical components important for the Mozart K448 effect in epilepsy.

Autor: Quon RJ; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Robert.J.Quon.GR@dartmouth.edu.; Department of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH, 03766, USA. Robert.J.Quon.GR@dartmouth.edu., Casey MA; Department of Music at Dartmouth College, Hanover, NH, USA.; Department of Computer Science at Dartmouth College, Hanover, NH, USA., Camp EJ; Department of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH, 03766, USA., Meisenhelter S; Department of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH, 03766, USA., Steimel SA; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Song Y; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; Department of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH, 03766, USA., Testorf ME; Department of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH, 03766, USA.; Thayer School of Engineering at Dartmouth College, Hanover, NH, USA., Leslie GA; Department of Music, Georgia Institute of Technology, Atlanta, GA, USA., Bujarski KA; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; Department of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH, 03766, USA., Ettinger AB; United Diagnostics, New Hyde Park, NY, USA., Jobst BC; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; Department of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH, 03766, USA.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Sep 16; Vol. 11 (1), pp. 16490. Date of Electronic Publication: 2021 Sep 16.
DOI: 10.1038/s41598-021-95922-7
Abstrakt: There is growing evidence for the efficacy of music, specifically Mozart's Sonata for Two Pianos in D Major (K448), at reducing ictal and interictal epileptiform activity. Nonetheless, little is known about the mechanism underlying this beneficial "Mozart K448 effect" for persons with epilepsy. Here, we measured the influence that K448 had on intracranial interictal epileptiform discharges (IEDs) in sixteen subjects undergoing intracranial monitoring for refractory focal epilepsy. We found reduced IEDs during the original version of K448 after at least 30-s of exposure. Nonsignificant IED rate reductions were witnessed in all brain regions apart from the bilateral frontal cortices, where we observed increased frontal theta power during transitions from prolonged musical segments. All other presented musical stimuli were associated with nonsignificant IED alterations. These results suggest that the "Mozart K448 effect" is dependent on the duration of exposure and may preferentially modulate activity in frontal emotional networks, providing insight into the mechanism underlying this response. Our findings encourage the continued evaluation of Mozart's K448 as a noninvasive, non-pharmacological intervention for refractory epilepsy.
(© 2021. The Author(s).)
Databáze: MEDLINE
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