Serum creatinine is a poor marker of a predicted change in muscle mass in lactating sows.

Autor: Muller TL; SunPork Group, Eagle Farm, Queensland, Australia.; Agricultural Sciences, College of Science, Health, Engineering and Education, Murdoch University, Murdoch, Western Australia, Australia., Pluske JR; Agricultural Sciences, College of Science, Health, Engineering and Education, Murdoch University, Murdoch, Western Australia, Australia., Plush KJ; SunPork Group, Eagle Farm, Queensland, Australia., D'Souza DN; SunPork Group, Eagle Farm, Queensland, Australia., Miller DW; Agricultural Sciences, College of Science, Health, Engineering and Education, Murdoch University, Murdoch, Western Australia, Australia., van Barneveld RJ; SunPork Group, Eagle Farm, Queensland, Australia.
Jazyk: angličtina
Zdroj: Journal of animal physiology and animal nutrition [J Anim Physiol Anim Nutr (Berl)] 2022 Sep; Vol. 106 (5), pp. 1009-1016. Date of Electronic Publication: 2021 Sep 15.
DOI: 10.1111/jpn.13637
Abstrakt: Serum creatinine (SCr) in humans has proven to be a reliable biomarker of body protein breakdown and/or muscle mass change. This study set out to investigate the potential of SCr to indicate a loss in sow muscle mass over lactation, validated against 3 methyl histidine (3MH) and blood urea nitrogen (BUN), markers of dietary and/or body protein breakdown. A total of 40 sows were allocated to four treatment groups aimed to induce body weight changes by restrictively feeding sows using a stepwise percentage reduction model. Data were pooled and reallocated into three groups representing the 25 th , 50 th and 75 th percentiles based on body weight change over lactation in the range -22.3 to -4.1% (treatment 25), -4.0 to 6.2% (Treatment 50), and 6.3-15.2% (Treatment 75). Indirect measures for the prediction of protein (3MH, BUN) or fat change (caliper, P2) were taken on entry into the farrowing house, day 5 of lactation, and at weaning. Serum was collected on these days, and SCr, 3MH and BUN were analysed. Piglet weaning weight and average daily feed intake did not differ between treatments (p > .05). There were no changes (p > .05) in indirect measures of body composition (sow caliper score, P2) and analytes (SCr, 3MH, BUN) over lactation. By day 20, those sows in treatment 25 had higher (p < .05) 3MH concentrations whilst changes from day 5 to 20 were not different (p > .05) and did not correlate with SCr change (p > .05) but were highly correlated to BUN change (R 2 = 0.691, p < .001). The data suggested that concentrations of SCr and BUN may have been the result of dietary and/or body protein breakdown and/or changes in muscle mass. In the current testing conditions, SCr was not a reliable marker of changes in muscle mass.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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