Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks.

Autor: Keita AK; Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université de Conakry, Conakry, Guinea. alpha-kabinet.keita@umontpellier.fr.; TransVIHMI, Montpellier University/IRD/INSERM, Montpellier, France. alpha-kabinet.keita@umontpellier.fr., Koundouno FR; Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG), Conakry, Guinea.; Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany., Faye M; Institut Pasteur de Dakar (IPD), Dakar, Senegal., Düx A; Robert Koch Institute (RKI), Berlin, Germany., Hinzmann J; Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.; UK Health Security Agency, National Infection Service, Porton Down, Salisbury, UK., Diallo H; Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université de Conakry, Conakry, Guinea., Ayouba A; TransVIHMI, Montpellier University/IRD/INSERM, Montpellier, France., Le Marcis F; Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université de Conakry, Conakry, Guinea.; TransVIHMI, Montpellier University/IRD/INSERM, Montpellier, France.; Ecole Nationale Supérieure de Lyon, Lyon, France., Soropogui B; Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG), Conakry, Guinea., Ifono K; Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG), Conakry, Guinea.; Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany., Diagne MM; Institut Pasteur de Dakar (IPD), Dakar, Senegal., Sow MS; Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université de Conakry, Conakry, Guinea.; Hôpital National Donka, Service des Maladies Infectieuses et Tropicales, Conakry, Guinea., Bore JA; Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG), Conakry, Guinea.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Calvignac-Spencer S; Robert Koch Institute (RKI), Berlin, Germany., Vidal N; TransVIHMI, Montpellier University/IRD/INSERM, Montpellier, France., Camara J; Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG), Conakry, Guinea., Keita MB; Institut National de Santé Publique de Guinée (INSP), Conakry, Guinea., Renevey A; Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Diallo A; Institut Pasteur de Dakar (IPD), Dakar, Senegal., Soumah AK; Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université de Conakry, Conakry, Guinea., Millimono SL; Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG), Conakry, Guinea.; Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany., Mari-Saez A; Robert Koch Institute (RKI), Berlin, Germany., Diop M; Institut Pasteur de Dakar (IPD), Dakar, Senegal., Doré A; Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG), Conakry, Guinea., Soumah FY; Hôpital National Donka, Service des Maladies Infectieuses et Tropicales, Conakry, Guinea., Kourouma K; Institut National de Santé Publique de Guinée (INSP), Conakry, Guinea., Vielle NJ; Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.; World Health Organization (WHO), Conakry, Guinea., Loucoubar C; Institut Pasteur de Dakar (IPD), Dakar, Senegal., Camara I; Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université de Conakry, Conakry, Guinea., Kourouma K; Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG), Conakry, Guinea.; Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany., Annibaldis G; Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.; World Health Organization (WHO), Conakry, Guinea., Bah A; Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG), Conakry, Guinea., Thielebein A; Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Pahlmann M; Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Pullan ST; UK Health Security Agency, National Infection Service, Porton Down, Salisbury, UK.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Carroll MW; UK Health Security Agency, National Infection Service, Porton Down, Salisbury, UK.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Quick J; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK., Formenty P; Health Emergencies Program, World Health Organization (WHO), Geneva, Switzerland., Legand A; Health Emergencies Program, World Health Organization (WHO), Geneva, Switzerland., Pietro K; PraesensBio, Lincoln, NE, USA., Wiley MR; PraesensBio, Lincoln, NE, USA.; University of Nebraska Medical Center, Omaha, NE, USA., Tordo N; Institut Pasteur de Guinée, Conakry, Guinea., Peyrefitte C; Institut Pasteur de Dakar (IPD), Dakar, Senegal., McCrone JT; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK., Rambaut A; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK., Sidibé Y; Hôpital Régional de Nzérékoré, Nzérékoré, Guinea., Barry MD; Hôpital Régional de Nzérékoré, Nzérékoré, Guinea., Kourouma M; Hôpital Régional de Nzérékoré, Nzérékoré, Guinea., Saouromou CD; Hôpital Régional de Nzérékoré, Nzérékoré, Guinea., Condé M; Hôpital Régional de Nzérékoré, Nzérékoré, Guinea., Baldé M; Hôpital National Donka, Service des Maladies Infectieuses et Tropicales, Conakry, Guinea., Povogui M; Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université de Conakry, Conakry, Guinea., Keita S; Agence Nationale de Sécurité Sanitaire, Conakry, Guinea., Diakite M; Direction Nationale des Laboratoires, Ministère de la Santé, Conakry, Guinea.; Université Gamal Abdel Nasser de Conakry, Conakry, Guinea., Bah MS; Direction Nationale des Laboratoires, Ministère de la Santé, Conakry, Guinea., Sidibe A; Ecole Nationale Supérieure de Lyon, Lyon, France., Diakite D; Hôpital National Donka, Service des Maladies Infectieuses et Tropicales, Conakry, Guinea., Sako FB; Hôpital National Donka, Service des Maladies Infectieuses et Tropicales, Conakry, Guinea., Traore FA; Hôpital National Donka, Service des Maladies Infectieuses et Tropicales, Conakry, Guinea., Ki-Zerbo GA; World Health Organization (WHO), Conakry, Guinea., Lemey P; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium., Günther S; Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.; World Health Organization (WHO), Conakry, Guinea., Kafetzopoulou LE; Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium., Sall AA; Institut Pasteur de Dakar (IPD), Dakar, Senegal., Delaporte E; TransVIHMI, Montpellier University/IRD/INSERM, Montpellier, France.; Infectious Diseases Departement, University Hospital Montpellier, Montpellier, France., Duraffour S; Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.; World Health Organization (WHO), Conakry, Guinea., Faye O; Institut Pasteur de Dakar (IPD), Dakar, Senegal., Leendertz FH; Robert Koch Institute (RKI), Berlin, Germany., Peeters M; TransVIHMI, Montpellier University/IRD/INSERM, Montpellier, France., Toure A; Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université de Conakry, Conakry, Guinea.; Institut National de Santé Publique de Guinée (INSP), Conakry, Guinea., Magassouba NF; Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG), Conakry, Guinea.
Jazyk: angličtina
Zdroj: Nature [Nature] 2021 Sep; Vol. 597 (7877), pp. 539-543. Date of Electronic Publication: 2021 Sep 15.
DOI: 10.1038/s41586-021-03901-9
Abstrakt: Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the country faced a new outbreak-between 14 February and 19 June 2021-near the epicentre of the previous epidemic 1,2 . Here we use next-generation sequencing to generate complete or near-complete genomes of Zaire ebolavirus from samples obtained from 12 different patients. These genomes form a well-supported phylogenetic cluster with genomes from the previous outbreak, which indicates that the new outbreak was not the result of a new spillover event from an animal reservoir. The 2021 lineage shows considerably lower divergence than would be expected during sustained human-to-human transmission, which suggests a persistent infection with reduced replication or a period of latency. The resurgence of Zaire ebolavirus from humans five years after the end of the previous outbreak of Ebola virus disease reinforces the need for long-term medical and social care for patients who survive the disease, to reduce the risk of re-emergence and to prevent further stigmatization.
(© 2021. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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