Cohort profile: a migratory cohort study of US Marines who train in Australia.

Autor:	Chan-Cuzydlo A; The Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Harrison DJ; Naval Medical Research Center, Frederick, Maryland, USA., Pike BL; Naval Medical Research Center, Frederick, Maryland, USA., Currie BJ; Department of Infectious Diseases, Menzies School of Health Research, Casuarina, Northern Territory, Australia.; Department of Infectious Diseases, Royal Darwin Hospital, Casuarina, Northern Territory, Australia., Mayo M; Menzies School of Health Research, Casuarina, Northern Territory, Australia., Salvador MG; The Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Hulsey WR; The Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Azzarello J; 1st Marine Division, Marine Corps Base Camp Pendleton, California, USA., Ellis J; 1st Marine Division, Marine Corps Base Camp Pendleton, California, USA., Kim D; 1st Marine Division, Marine Corps Base Camp Pendleton, California, USA., King-Lewis W; 1st Marine Division, Marine Corps Base Camp Pendleton, California, USA., Smith JN; 1st Marine Division, Marine Corps Base Camp Pendleton, California, USA., Rodriguez B; 1st Marine Division, Marine Corps Base Camp Pendleton, California, USA., Maves RC; Division of Infectious Diseases, Naval Medical Center San Diego, San Diego, California, USA., Lawler JV; Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA., Schully KL; Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), Naval Medical Research Center, Silver Spring, Maryland, USA kevin.l.schully.civ@mail.mil.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2021 Sep 15; Vol. 11 (9), pp. e050330. Date of Electronic Publication: 2021 Sep 15.
DOI:	10.1136/bmjopen-2021-050330
Abstrakt:	Purpose: In 2012, US Marines and Sailors began annual deployments to Australia to participate in joint training exercises with the Australian Defence Force and other partners in the region. During their training, US service members are exposed to a variety of infectious disease threats not normally encountered by American citizens. This paper describes a cohort of US Marines and Sailors enrolled during five rotations to Australia between 2016 and 2020. Participants: Study participation is strictly voluntary. Group informational sessions are held prior to deployment to describe the study structure and goals, as well as the infectious disease threats that participants may encounter while in Australia. All participants provided written informed consent. Consented participants complete a pre-deployment questionnaire to collect data including basic demographic information, military occupational specialty, travel history, family history, basic health status and personal habits such as alcohol consumption. Blood is collected for serum, plasma and peripheral blood mononuclear cells (PBMC) processing. Data and specimen collection is repeated up to three times: before, during and after deployment. Findings to Date: From the five rotations that comprised the 2016-2020 Marine Rotational Force-Darwin, we enrolled 1289 volunteers. Enrolments during this period were overwhelmingly white male under the age of 24 years. Most of the enrollees were junior enlisted and non-commissioned officers, with a smaller number of staff non-commissioned officers and commissioned officers, and minimal warrant officers. Over half of the enrollees had occupational specialty designations for infantry. Future Plans: In the future, we will screen samples for serological evidence of infection with Burkholderia pseudomallei , Coxiella burnetii , Ross River virus, SARS-CoV-2 and other operationally relevant pathogens endemic in Australia. Antigenic stimulation assays will be performed on PBMCs collected from seropositive individuals to characterise the immune response to these infections in this healthy American population. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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