Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods.

Autor: Zhang F; Department of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China., Hou Y; Department of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China., Zhu M; Department of Otolaryngology Head & Neck Surgery, Shanghai Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China., Deng B; State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Wuhan, 430073, China., Zhao M; Department of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China., Zhu X; Department of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China., Sun Y; Department of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China., Chen D; Department of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China., Jiang C; Department of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China., Wang L; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing, 100049, China., Chen C; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing, 100049, China., Chen H; Department of Otolaryngology Head & Neck Surgery, Shanghai Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China., Chen H; Department of General Surgery, Navy No.905 Hospital of Chinese People's Liberation Army, Naval Medical University, Shanghai, 200050, China., Zheng H; Department of Otolaryngology Head & Neck Surgery, Shanghai Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China., Li W; Department of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China.
Jazyk: angličtina
Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2021 Nov; Vol. 8 (22), pp. e2102666. Date of Electronic Publication: 2021 Sep 15.
DOI: 10.1002/advs.202102666
Abstrakt: Necrosis induces strong inflammation with undesirable implications in clinics compared with apoptosis. Fortunately, the switch between necrosis and apoptosis could be realized by tailoring the appropriate structural properties of gold nano rods (GNRs) that could precisely modulate cell death pathways. Herein, the intracellular interaction between GNRs and organelles is monitored and it is found that lysosomes dominates necrosis/apoptosis evoking. Then the surface molecule density of GNRs, which is first defined as ρ surf. molecule (N surf. molecules /(a × π × Diameter × Length)), mediates lysosome activities as the membrane permeabilization (LMP), the Cathepsin B and D release, the cross-talk between lysosome and different organelles, which selectively evokes apoptosis or necrosis and the production of TNF-α from macrophages. GNRs with small ρ surf. molecule mainly induce apoptosis, while with large ρ surf. molecule they greatly contribute to necrosis. Interestingly, necrosis can be suppressed by GNRs with higher ρ surf. molecule due to the overexpression of key protease caspase 8, which cleaves the RIP1-RIP3 complex and activates caspase 3 followed by necrosis to apoptosis transition. This investigation indicates that the ρ surf. molecule greatly affects the utility of nanomaterials and different structural properties of nanomaterials have different implications in clinics.
(© 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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