Oral shedding of herpesviruses and clinical outcomes in hematopoietic stem cell transplant patients.

Autor: Miranda-Silva W; Instituto de Ensino e Pesquisa, Hospital Sírio-Libanês, São Paulo, Brazil., de Molla VC; Centro de Oncologia, Hospital Sírio-Libanes, São Paulo, Brazil.; Universidade Federal de São Paulo, São Paulo, Brazil., Knebel FH; Sociedade Beneficente de Senhoras Hospital Sírio Libanês, São Paulo, Brazil., Tozetto-Mendoza TR; Laboratory of Virology, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil., Arrais-Rodrigues C; Centro de Oncologia, Hospital Sírio-Libanes, São Paulo, Brazil.; Universidade Federal de São Paulo, São Paulo, Brazil., Camargo AA; Sociedade Beneficente de Senhoras Hospital Sírio Libanês, São Paulo, Brazil., Braz-Silva PH; Laboratory of Virology, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil.; Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil., Fregnani ER; Instituto de Ensino e Pesquisa, Hospital Sírio-Libanês, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Oral diseases [Oral Dis] 2023 Mar; Vol. 29 (2), pp. 815-826. Date of Electronic Publication: 2021 Sep 28.
DOI: 10.1111/odi.14022
Abstrakt: Objectives: To characterize the oral shedding of herpes viruses in patients who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) and investigate its relationship with clinical outcomes.
Materials and Methods: Polymerase chain reaction and enzymatic digestion were performed to identify the oral shedding of the members of the Herpesviridae family in 31 patients. The samples were collected from the oral cavity at five timestamps.
Results: The presence of each herpesvirus in the oral cavity was observed in 3.2%, 12.9%, 19.3%, 32.2%, 54.8% and 93.5% patients for human herpesvirus (HHV)-6A, herpes simplex virus-1, HHV-6B, cytomegalovirus (CMV), Epstein-Barr virus (EBV) and HHV-7, respectively. Oral shedding of herpes virus was not uncommon after alloHSCT. There was a statistically significant association between the EBV and CMV oral shedding at C1 and the cumulative incidence of acute graft-versus-host disease (aGVHD). The results suggested that the presence of HSV-1 at C2 was related to a relapse. The HHV-7 oral shedding at C2 suggests a possible link between relapse, progression-free survival and overall survival of the patients.
Conclusions: Patients who developed aGVHD showed higher CMV and EBV shedding in the oral cavity at aplasia, suggesting modifications to the pattern of immune cell response and inflammatory microenvironment.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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