Novel sulfonamide-chalcone hybrid stimulates inflammation, angiogenesis and upregulates vascular endothelial growth factor (VEGF) in vivo.

Autor: Silva LS; Laboratory of Radiobiology and Mutagenesis, Department of Genetics, Institute of Biological Sciences, Universidade Federal de Goiás, Goiânia, Brazil., Véras JH; Laboratory of Radiobiology and Mutagenesis, Department of Genetics, Institute of Biological Sciences, Universidade Federal de Goiás, Goiânia, Brazil., Fernandes AS; Laboratory of Radiobiology and Mutagenesis, Department of Genetics, Institute of Biological Sciences, Universidade Federal de Goiás, Goiânia, Brazil., de Melo Bisneto AV; Laboratory of Radiobiology and Mutagenesis, Department of Genetics, Institute of Biological Sciences, Universidade Federal de Goiás, Goiânia, Brazil., de Castro MRC; Chemistry Institute, Universidade Federal de Goiás, Goiânia, Brazil., Naves RF; Chemistry Institute, Universidade Federal de Goiás, Goiânia, Brazil., Carneiro CC; Department of Biomedicine, Pontifícia Universidade Católica de Goiás, Goiânia, Brazil., Pérez CN; Chemistry Institute, Universidade Federal de Goiás, Goiânia, Brazil., Cardoso CG; Laboratory of Radiobiology and Mutagenesis, Department of Genetics, Institute of Biological Sciences, Universidade Federal de Goiás, Goiânia, Brazil., Ribeiro E Silva C; Laboratory of Radiobiology and Mutagenesis, Department of Genetics, Institute of Biological Sciences, Universidade Federal de Goiás, Goiânia, Brazil., Chen-Chen L; Laboratory of Radiobiology and Mutagenesis, Department of Genetics, Institute of Biological Sciences, Universidade Federal de Goiás, Goiânia, Brazil. Electronic address: chenleego@yahoo.com.br.
Jazyk: angličtina
Zdroj: Microvascular research [Microvasc Res] 2022 Jan; Vol. 139, pp. 104253. Date of Electronic Publication: 2021 Sep 11.
DOI: 10.1016/j.mvr.2021.104253
Abstrakt: Chalcones and sulfonamides are well-known chemical groups associated with several biological activities such as antibiotic, anti-inflammatory, and antitumor activities. Over the past few decades, a series of sulfonamide-chalcone hybrids have been synthesized and assessed to develop compounds with interesting biological properties for application in disease therapy. In the present study, a new sulfonamide-chalcone hybrid μ - (2,5-dichloro-N-{4-[(3E)-4-(3-nitrophenyl) buta-1,3-dien-2-yl] phenyl} benzene sulfonamide), or simply CL185, was synthesized, and its angiogenic activity was assessed using the chick embryo chorioallantoic membrane (CAM) assay at different concentrations (12.5, 25, and 50 μg/μL). To further investigate the role of CL185 in the angiogenic process, we evaluated the levels of vascular endothelial growth factor (VEGF) in all treated CAMs. The results showed that all concentrations of CL185 significantly increased tissue vascularization (p < 0.05) as well as the parameters associated with angiogenesis, in which inflammation was the most marked phenomenon observed. In all CAMs treated with CL185, VEGF levels were significantly higher than those in the negative control (p < 0.05), and at the highest concentration, VEGF levels were even higher than in the positive control (p < 0.05). The pronounced angiogenic activity displayed by CL185 may be related to the increase in VEGF levels that were stimulated by inflammatory processes observed in our study. Therefore, CL185 presents a favorable profile for the development of drugs that can be used in pro-angiogenic and tissue repair therapies.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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