Can we trust in Sars-CoV-2 rapid antigen testing? Preliminary results from a paediatric cohort in the emergency department.

Autor: Denina M; Department of Pediatric Emergency, Regina Margherita Children's Hospital, Turin, Italy. marco.denina@gmail.com.; Department of Pediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Children's Hospital, Turin, Italy. marco.denina@gmail.com., Giannone V; Department of Pediatrics and Public Health, University of Turin, Regina Margherita Children's Hospital, Turin, Italy., Curtoni A; Department of Public Health and Pediatrics, Microbiology and Virology Unit, Molinette Hospital, University of Turin, Città della salute e della Scienza, Turin, Italy., Zanotto E; Department of Public Health and Pediatrics, Microbiology and Virology Unit, Molinette Hospital, University of Turin, Città della salute e della Scienza, Turin, Italy., Garazzino S; Department of Pediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Children's Hospital, Turin, Italy., Urbino AF; Department of Pediatric Emergency, Regina Margherita Children's Hospital, Turin, Italy., Bondone C; Department of Pediatric Emergency, Regina Margherita Children's Hospital, Turin, Italy.
Jazyk: angličtina
Zdroj: Irish journal of medical science [Ir J Med Sci] 2022 Aug; Vol. 191 (4), pp. 1767-1770. Date of Electronic Publication: 2021 Sep 14.
DOI: 10.1007/s11845-021-02776-z
Abstrakt: Background: Rapid identification of Covid-19 in the paediatric emergency department is critical; Antigen tests are fast but poorly investigated in children.
Aims: To investigate Sars-CoV-2 antigen rapid test in children.
Methods: We compare the performance of LumiraDx with molecular tests in a paediatric emergency department.
Results: A retrospective cohort of 191 patients with AT and PCR tests performed in the same episode was analysed; 16% resulted positive for Sars-CoV-2. Using the PCR test as the gold standard, we calculated antigen testing overall sensitivity of 94.1%, specificity of 91.9%, and NPV of 99.4%. Only one false-negative test was found.
Conclusions: AT may be helpful in the initial screening of patients at PED.
(© 2021. Royal Academy of Medicine in Ireland.)
Databáze: MEDLINE
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