Investigation of the effects of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on anemia in patients with normal or mildly low glomerular filtration rate

Autor: Ergün B; Department of Internal Medicine, Health Science University, Keçioren Training and Research Hospital, Ankara, Turkey., Aybal Kutlugün A; Division of Nephrology, Department of Internal Medicine, Health Science University, Keçiören Training and Research Hospital, Ankara, Turkey., Ergün MÇ; Division of Rheumatology, Deparrtment of Internal Medicine, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey., Aktürk G; Department of Internal Medicine, Polatlı Duatepe Hospital, Ankara, Turkey., Beyan E; Department of Internal Medicine, Health Science University, Keçioren Training and Research Hospital, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Turkish journal of medical sciences [Turk J Med Sci] 2021 Dec 13; Vol. 51 (6), pp. 3047-3052. Date of Electronic Publication: 2021 Dec 13.
DOI: 10.3906/sag-2104-138
Abstrakt: Background/aim: The relationship between the activation of the renin-angiotensin system and the increase in erythropoiesis has been shown in many studies. In addition, the use of angiotensin converting enzyme inhibitors (ACEIs) or angiotensin-receptor blockers (ARB) has been reported to reduce hemoglobin levels in various patient groups at risk for secondary erythrocytosis/polycythemia. The aim of our study is to investigate whether there is a change in hemoglobin levels after starting ACEIs or ARBs in patients who have not used them before.
Materials and Methods: Three hundred and fifty-one patients who were started on renin angiotensin aldosterone system (RAAS) blockers were evaluated retrospectively. None of the patients had anemia before starting RAAS blockers. A median of 6 (4–12) months after the start of the drug, complete blood count and kidney function tests were evaluated. Hemoglobin values before and after the start of the drug were compared statistically.
Results: A statistically significant decrease in mean Hb value was found after starting ACEIs or ARBs (14.39± 1.29 g/dL vs 13.98 ± 1.36 g/dL, p < 0.001). The decrease in control Hb values was higher in the ARB group than in the ACEI group (–0.53 ± 0.06 g/dL vs –0.29 ± 0.06 g/dL, p < 0.001).
Conclusion: A significant decrease in mean Hb level was detected in the first year following the first administration of ACEIs or ARBs.
Competing Interests: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper
(This work is licensed under a Creative Commons Attribution 4.0 International License.)
Databáze: MEDLINE
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