Overfeeding during development induces temporally-dependent changes in areas controlling food intake in the brains of male Wistar rats.

Autor: de Andrade Silva SC; Neuropsychiatry and Behavior Science Graduate Program, Universidade Federal de Pernambuco -UFPE-Recife, PE, Brazil., da Silva AI; Neuropsychiatry and Behavior Science Graduate Program, Universidade Federal de Pernambuco -UFPE-Recife, PE, Brazil., Braz GRF; Neuropsychiatry and Behavior Science Graduate Program, Universidade Federal de Pernambuco -UFPE-Recife, PE, Brazil., da Silva Pedroza AA; Laboratory of Biochemistry and Exercise Biochemistry, Universidade Federal de Pernambuco - UFPE, Recife, PE, Brazil., de Lemos MDT; Laboratory of Biochemistry and Exercise Biochemistry, Universidade Federal de Pernambuco - UFPE, Recife, PE, Brazil., Sellitti DF; Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Lagranha C; Neuropsychiatry and Behavior Science Graduate Program, Universidade Federal de Pernambuco -UFPE-Recife, PE, Brazil; Laboratory of Biochemistry and Exercise Biochemistry, Universidade Federal de Pernambuco - UFPE, Recife, PE, Brazil. Electronic address: claudia.lagranha@ufpe.br.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2021 Nov 15; Vol. 285, pp. 119951. Date of Electronic Publication: 2021 Sep 11.
DOI: 10.1016/j.lfs.2021.119951
Abstrakt: Aims: We sought to evaluate the effects of overfeeding during lactation on the feeding behavior and expression of specific regulatory genes in brain areas associated with food intake in 22- and 60-day old male rats.
Methods: We evaluated body weight, food intake of standard and palatable diet, and mRNA expression of dopamine receptor D1 (DDR1), dopamine receptor (DDR2), melanocortin 4 receptor (MC4R), the μ-opioid receptor (MOR), neuropeptide Y (NPY), agouti-related protein (AGRP), proopiomelanocortin (POMC), cocaine-and amphetamine-regulated transcript (CART), serotonin (5-hydroxytryptamine; 5-HT) transporter (SERT), 5-hydroxytryptamine receptor 1B (5-HT1B), 5-hydroxytryptamine receptor 2C receptor (5-HT2C), Clock (CLOK), cryptochrome protein 1 (Cry1) and period circadian protein homolog 2 (Per2) in the striatum, hypothalamus and brainstem of male rats at post-natal days (PND) 22 and 60.
Key Findings: Overfeeding resulted in significantly increased body weight through PND60, and a 2-fold increase in palatable food intake at PND22, but not at PND60. We observed significant increases in DDR1, DDR2, and MC4R gene expression in the striatum and brainstem and POMC/CART in the hypothalamus of the OF group at PND22 that were reversed by PND60. Hypothalamic levels of 5-HT1B, 5-HT2C and NPY/AGRP on the other hand were decreased at PND22 and increased at PND60 in OF animals. Clock genes were unaffected by OF at PND22, but were significantly elevated at PND60.
Significance: Overfeeding during early development of the rat brain results in obesity and altered feeding behavior in early adulthood. The altered behavior might be the consequence of the changes in food intake and reward gene expression.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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