Effects of Autologous Platelet-Rich Plasma in women with repeated implantation failure undergoing assisted reproduction.

Autor:	Bakhsh AS; Avicenna Fertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran., Maleki N; Avicenna Fertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran.; Gynecology and reproductive biology Department, Kowsar polyclinic, Imam Khomeini square, Pardis Town, Tehran Province, Iran., Sadeghi MR; Avicenna Fertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran.; Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran., SadeghiTabar A; Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran., Tavakoli M; Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran., Zafardoust S; Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran., Karimi A; Avicenna Fertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran.; Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran., Askari S; Avicenna Fertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran., Jouhari S; Avicenna Fertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran.; Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran., Mohammadzadeh A; Avicenna Fertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran.; Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.; Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	JBRA assisted reproduction [JBRA Assist Reprod] 2022 Jan 17; Vol. 26 (1), pp. 84-87. Date of Electronic Publication: 2022 Jan 17.
DOI:	10.5935/1518-0557.20210046
Abstrakt:	Objective: Repeated implantation failure (RIF) is a major challenge in reproductive medicine. On the other hand, there has not yet been established a confirmed outcome regarding the usage of platelet-rich plasma (PRP) in women undergoing intracytoplasmic injection (ICSI) or in-vitro fertilization (IVF); hence, the objective of this study was to evaluate the effect of the intrauterine infusion of PRP on pregnancy outcomes in women undergoing ICSI. Methods: In this prospective double-blind clinical trial, 100 women with at least two previous unexplained RIF, who were candidates for frozen-thawed embryo transfer, were allocated into two groups. One subgroup of patients was treated by intrauterine infusion of PRP (0.5CC, contained platelet 4-5 times more than a peripheral blood sample, which was performed 48 hours before blastocyst transfer) and the other subgroup was treated by intrauterine catheterization only. We compared the implantation rates between the two groups. Results: The pregnancy rate was 20% in the intervention subgroup, while in the control subgroup it was 13.33%; therefore, there was a significant statistical difference between the two groups. Conclusions: According to this paper, PRP could be successful in improving the pregnancy outcome in RIF patients, and we highly recommend other studies with larger samples to confirm the PRP therapy efficacy in RIF patients.
Databáze:	MEDLINE
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