Treatment of Homozygous Type II Antithrombin Heparin-Binding Site Deficiency in Pregnancy.

Autor: Fiskvik H; Department of Hematology, Oslo University Hospital, Oslo, Norway., Jacobsen AF; Department of Obstetrics and Gynecology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Norway., Iversen N; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Henriksson CE; Institute of Clinical Medicine, University of Oslo, Norway.; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway., Jacobsen EM; Department of Hematology, Oslo University Hospital, Oslo, Norway.
Jazyk: angličtina
Zdroj: Case reports in obstetrics and gynecology [Case Rep Obstet Gynecol] 2021 Sep 03; Vol. 2021, pp. 4393821. Date of Electronic Publication: 2021 Sep 03 (Print Publication: 2021).
DOI: 10.1155/2021/4393821
Abstrakt: Pregnancy is associated with an increased risk of venous thromboembolism (VTE). Previous VTE and severe thrombophilia are important risk factors. Our case was a 36-year-old woman, gravida 6, para 0, with antithrombin (AT) deficiency caused by a homozygous mutation in the heparin-binding site (HBS). Her history included seven prior VTEs, three early and two late pregnancy losses. She was prophylactically treated with both human plasma-derived AT concentrate (hpATC) and low molecular weight heparin (LMWH), resulting in a successful 6 th pregnancy and a healthy live born baby. There is limited evidence and guidance on the management of AT deficiency in pregnancy. Dosing and monitoring of anticoagulants, alone or together with hpATC, must be based on individual risk assessment. The severity of clinical manifestations varies with the type of AT deficiency. Characterization of the AT mutation may aid in the decision-making process and optimize pregnancy outcomes.
Competing Interests: The authors have no conflicts of interest to disclose.
(Copyright © 2021 Hilde Fiskvik et al.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje