Clinical Use of Progestins and Their Mechanisms of Action: Present and Future (Review).
| Autor: | Fedotcheva TA; Senior Researcher, Research Laboratory of Molecular Pharmacology, Pirogov Russian National Research Medical University, 1 Ostrovitianova St., Moscow, 117997, Russia. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Sovremennye tekhnologii v meditsine [Sovrem Tekhnologii Med] 2021; Vol. 13 (1), pp. 93-106. Date of Electronic Publication: 2021 Feb 28. |
| DOI: | 10.17691/stm2021.13.1.11 |
| Abstrakt: | This review summarizes the current opinions on the mechanisms of action of nuclear, mitochondrial, and membrane progesterone receptors. The main aspects of the pharmacological action of progestins have been studied. Data on the clinical use of gestagens by nosological groups are presented. Particular attention is paid to progesterone, megestrol acetate, medroxyprogesterone acetate due to broadening of their spectrum of action. The possibilities of using gestagens as neuroprotectors, immunomodulators, and chemosensitizers are considered. Competing Interests: Conflict of interest. The authors have no conflict of interest to disclose. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|