Cannabidiol Exposure During the Mouse Adolescent Period Is Without Harmful Behavioral Effects on Locomotor Activity, Anxiety, and Spatial Memory.

Autor:	Kaplan JS; Department of Psychology, Behavioral Neuroscience Program, Western Washington University, Bellingham, WA, United States., Wagner JK; Department of Psychology, Behavioral Neuroscience Program, Western Washington University, Bellingham, WA, United States., Reid K; Department of Psychology, Behavioral Neuroscience Program, Western Washington University, Bellingham, WA, United States., McGuinness F; Department of Psychology, Behavioral Neuroscience Program, Western Washington University, Bellingham, WA, United States., Arvila S; Department of Psychology, Behavioral Neuroscience Program, Western Washington University, Bellingham, WA, United States., Brooks M; Department of Psychology, Behavioral Neuroscience Program, Western Washington University, Bellingham, WA, United States., Stevenson H; Department of Psychology, Behavioral Neuroscience Program, Western Washington University, Bellingham, WA, United States., Jones J; Department of Psychology, Behavioral Neuroscience Program, Western Washington University, Bellingham, WA, United States., Risch B; Department of Psychology, Behavioral Neuroscience Program, Western Washington University, Bellingham, WA, United States.; Department of Psychology, Experimental Psychology Graduate Program, Western Washington University, Bellingham, WA, United States., McGillis T; Department of Psychology, Behavioral Neuroscience Program, Western Washington University, Bellingham, WA, United States., Budinich R; Department of Psychology, Behavioral Neuroscience Program, Western Washington University, Bellingham, WA, United States., Gambell E; Department of Psychology, Behavioral Neuroscience Program, Western Washington University, Bellingham, WA, United States., Predovich B; Prelabs, Lehigh Acres, FL, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in behavioral neuroscience [Front Behav Neurosci] 2021 Aug 26; Vol. 15, pp. 711639. Date of Electronic Publication: 2021 Aug 26 (Print Publication: 2021).
DOI:	10.3389/fnbeh.2021.711639
Abstrakt:	Cannabidiol (CBD) is a non-intoxicating phytocannabinoid whose purported therapeutic benefits and impression of a high safety profile has promoted its increasing popularity. CBD's popularity is also increasing among children and adolescents who are being administered CBD, off label, for the treatment of numerous symptoms associated with autism spectrum disorder, attention deficit hyperactivity disorder, anxiety, and depression. The relative recency of its use in the adolescent population has precluded investigation of its impact on the developing brain and the potential consequences that may present in adulthood. Therefore, there's an urgency to identify whether prolonged adolescent CBD exposure has substantive impacts on the developing brain that impact behavioral and cognitive processes in adulthood. Here, we tested the effect of twice-daily intraperitoneal administrations of CBD (20 mg/kg) in male and female C57BL/6J mice during the adolescent period of 25-45 days on weight gain, and assays for locomotor behavior, anxiety, and spatial memory. Prolonged adolescent CBD exposure had no detrimental effects on locomotor activity in the open field, anxiety behavior on the elevated plus maze, or spatial memory in the Barnes Maze compared to vehicle-treated mice. Interestingly, CBD-treated mice had a faster rate of learning in the Barnes Maze. However, CBD-treated females had reduced weight gain during the exposure period. We conclude that prolonged adolescent CBD exposure in mice does not have substantive negative impacts on a range of behaviors in adulthood, may improve the rate of learning under certain conditions, and impacts weight gain in a sex-specific manner. Competing Interests: BP is employed by Prelabs, LLC. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Kaplan, Wagner, Reid, McGuinness, Arvila, Brooks, Stevenson, Jones, Risch, McGillis, Budinich, Gambell and Predovich.)
Databáze:	MEDLINE
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