Myopia and Early-Onset Type 2 Diabetes: A Nationwide Cohort Study.

Autor:	Peled A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Ophthalmology, Assaf-Harofeh Medical Center, Zerifin, Israel., Raz I; The Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel., Zucker I; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Ministry of Health, Israel Center for Disease Control, Ramat Gan, Israel., Derazne E; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Megreli J; Hebrew University-Hadassah Braun School of Public Health and Community, Jerusalem, Israel.; Israel Defense Forces Medical Corps, Ramat Gan, Israel., Pinhas-Hamiel O; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan, Israel., Einan-Lifshitz A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Ophthalmology, Assaf-Harofeh Medical Center, Zerifin, Israel., Morad Y; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Ophthalmology, Assaf-Harofeh Medical Center, Zerifin, Israel., Pras E; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Ophthalmology, Assaf-Harofeh Medical Center, Zerifin, Israel., Lutski M; Ministry of Health, Israel Center for Disease Control, Ramat Gan, Israel., Cukierman-Yaffe T; Ministry of Health, Israel Center for Disease Control, Ramat Gan, Israel.; Institute of Endocrinology, Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan, Israel., Mosenzon O; The Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel., Tzur D; Israel Defense Forces Medical Corps, Ramat Gan, Israel.; Department of Military Medicine, Hebrew University, Jerusalem, Israel., Tirosh A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Institute of Endocrinology, Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan, Israel., Gerstein HC; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Afek A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Central Management, Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan, Israel., Twig G; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Israel Defense Forces Medical Corps, Ramat Gan, Israel.; Institute of Endocrinology, Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan, Israel.; Department of Military Medicine, Hebrew University, Jerusalem, Israel.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 Jan 18; Vol. 107 (2), pp. e663-e671.
DOI:	10.1210/clinem/dgab669
Abstrakt:	Context: A correlation between myopia and insulin resistance has been suggested. Objective: We investigated the association between myopia in adolescence and type 2 diabetes (T2D) incidence in young adulthood. Methods: This population-based, retrospective, cohort study comprised 1 329 705 adolescents (579 543 women, 43.6%) aged 16 to 19 years, who were medically examined before mandatory military service during 1993 to 2012, and whose data were linked to the Israel National Diabetes Registry. Myopia was defined based on right-eye refractive data. Cox proportional models were applied, separately for women and men, to estimate hazard ratios (HRs) for T2D incidence per person-years of follow-up. Results: There was an interaction between myopia and sex with T2D (P < .001). For women, T2D incidence rates (per 100 000 person-years) were 16.6, 19.2, and 25.1 for those without myopia, and with mild-to-moderate and high myopia, respectively. These corresponded to HRs of 1.29 (95% CI, 1.14-1.45) and 1.63 (1.21-2.18) for women with mild-to-moderate and high myopia, respectively, compared to those without myopia, after adjustment for age at study entry, birth year, adolescent body mass index, cognitive performance, socioeconomic status, and immigration status. Results persisted in extensive sensitivity and subgroup analyses. When managed as a continuous variable, every 1-diopter lower spherical equivalent yielded a 6.5% higher adjusted HR for T2D incidence (P = .003). There was no significant association among men. Conclusion: For women, myopia in adolescence was associated with a significantly increased risk for incident T2D in young adulthood, in a severity-dependent manner. This finding may support the role of insulin resistance in myopia pathogenesis. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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