Primary, secondary or less frequent causes of immune thrombocytopenia: A case report.

Autor: Onisâi M; Hematology Clinic, Emergency University Hospital, 050098 Bucharest, Romania.; Department of Hematology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Vlădăreanu AM; Hematology Clinic, Emergency University Hospital, 050098 Bucharest, Romania.; Department of Hematology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Iordan I; Hematology Clinic, Emergency University Hospital, 050098 Bucharest, Romania.; Department of Hematology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Bumbea H; Hematology Clinic, Emergency University Hospital, 050098 Bucharest, Romania.; Department of Hematology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Găman M; Hematology Clinic, Emergency University Hospital, 050098 Bucharest, Romania.; Department of Hematology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Ciufu C; Hematology Clinic, Emergency University Hospital, 050098 Bucharest, Romania.; Department of Hematology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Voican I; Hematology Clinic, Emergency University Hospital, 050098 Bucharest, Romania., Cîșleanu D; Hematology Clinic, Emergency University Hospital, 050098 Bucharest, Romania.; Department of Hematology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Vasile D; Hematology Clinic, Emergency University Hospital, 050098 Bucharest, Romania.; Department of Hematology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Marinescu C; Hematology Clinic, Emergency University Hospital, 050098 Bucharest, Romania.; Department of Hematology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Nicolescu A; Hematology Clinic, Emergency University Hospital, 050098 Bucharest, Romania., Spînu A; Hematology Clinic, Emergency University Hospital, 050098 Bucharest, Romania.; Department of Hematology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Nistor R; Neurology Clinic, Emergency University Hospital, 050098 Bucharest, Romania.; Department of Neurology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Alexandru A; Department of Plastic Reconstructive Surgery, Emergency University Hospital, 050098 Bucharest, Romania.; Department of Plastic Surgery, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Jazyk: angličtina
Zdroj: Experimental and therapeutic medicine [Exp Ther Med] 2021 Oct; Vol. 22 (4), pp. 1096. Date of Electronic Publication: 2021 Aug 02.
DOI: 10.3892/etm.2021.10530
Abstrakt: Primary immune thrombocytopenia (ITP) is characterized by isolated low platelet count and it is a diagnosis of exclusion, contrasting to secondary ITP. Therefore, a positive diagnosis is difficult and requires extensive investigation. Some of the underlying conditions that are associated with ITP are lymphoproliferative disorders and infections, especially viral ones. In the present study, the case of a patient diagnosed with diffuse large B-cell lymphoma, who received chemotherapy and autologous hematopoietic stem cell transplantation is presented. After a complete remission of four years, the patient presented with sudden intense hemorrhagic syndrome and severely decreased platelet count. The most frequent causes of secondary ITP were excluded, including lymphoma relapse, and intravenous corticosteroids were started. However, shortly after hospital admission, the patient developed neuro-psychiatric anomalies, fever and pancytopenia, and West-Nile encephalitis was diagnosed. Although the initial development was favorable, he started to complain of progressive severe muscle weakness and eventually succumbed to infectious complications in the setting of prolonged hospitalization, corticotherapy, and immobilization.
Competing Interests: The authors declare that they have no competing interests.
(Copyright © 2020, Spandidos Publications.)
Databáze: MEDLINE
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