Plasma Levels of a Product of Free Radical Injury and Antioxidant Status of Patients with Different Grades of Plasmodium Falciparum Infection.

Autor:	Atiba AS; Department of Chemical Pathology, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria. Email: samuel.atiba@eksu.edu.ng; +2347030454127., Bello NO; Department of Obstetrics and Gynaecology, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria., Niran-Atiba TA; Department of Biomedical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria., Ogunjinmi OE; Department of Physical Sciences, First Technical University, Ibadan, Oyo State, Nigeria., Edogun HA; Department of Medical Microbiology and Parasitology, Ekiti State University Teaching Hospital, Ado-Ekiti, Ekiti State, Nigeria., Bamisi OD; Department of Anatomy, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria., Daramola AO; Department of Haematology and Blood Transfusion, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria., Awosanya JA; Department of Medical Microbiology and Parasitology, Ekiti State University Teaching Hospital, Ado-Ekiti, Ekiti State, Nigeria., Oparinde DP; Department of Chemical Pathology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Jazyk:	angličtina
Zdroj:	West African journal of medicine [West Afr J Med] 2021 Aug 30; Vol. 38 (8), pp. 770-774.
Abstrakt:	Background: Plasmodium falciparum infection, like any other clinical condition, is prone to generating free radicals. This can worsen patients' clinical presentations. Antioxidants do help in ameliorating these free radical effects. These antioxidants, especially vitamins, are sometimes given routinely to patients with Plasmodium falciparum infection of which it can be given according to the severity of this free radical injury. Methodology: A total number of qualified 245 patients that came for malaria parasite test between March and October, 2020 were recruited into the study. Patients on arrival at the laboratory had their samples collected for malaria parasite test and for the proposed biochemical parameters (MDA, GPx, SOD and TAS). Malaria parasite test was used to categorize the severity of Plasmodium falciparum infection. Results: There were statistically significant differences (p<0.0001) in MDA, GPx, SOD and TAS among patients with negative MP, 1+ and >2+ on blood film for malaria parasite. Patients with >2+ MP had highest levels (2.21±0.40) while patients with negative blood film had lowest levels(0.8194±0.33) of MDA. Patients with >2+ had lowest levels of GPx (2406.41±1272.10), SOD (104.54±30.62) and TAS (1.18±.35) as against patients with negative MP that had highest levels (5229.85±.2957.95)( 206.41±36.70)( 2.40±.53), respectively. Conclusion: There was evidence of free radical generation as evidenced with raised plasma malondialdehyde in patients with Plasmodium falciparum infection. This was associated with severity of this infection. There was also corresponding decrease in measured antioxidants (GPx, SOD and TAS). Competing Interests: The Authors declare that no competing interest exists. (Copyright © 2021 by West African Journal of Medicine.)
Databáze:	MEDLINE
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