Modification of Arabinogalactan Isolated from Larix sibirica Ledeb. into Sulfated Derivatives with the Controlled Molecular Weights.

Autor:	Malyar YN; School of Non-Ferrous Metals and Material Science, Siberian Federal University, Pr. Svobodny, 79, 660041 Krasnoyarsk, Russia.; Institute of Chemistry and Chemical Technology, Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok, 50/24, 660036 Krasnoyarsk, Russia., Vasilyeva NY; School of Non-Ferrous Metals and Material Science, Siberian Federal University, Pr. Svobodny, 79, 660041 Krasnoyarsk, Russia.; Institute of Chemistry and Chemical Technology, Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok, 50/24, 660036 Krasnoyarsk, Russia., Kazachenko AS; School of Non-Ferrous Metals and Material Science, Siberian Federal University, Pr. Svobodny, 79, 660041 Krasnoyarsk, Russia.; Institute of Chemistry and Chemical Technology, Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok, 50/24, 660036 Krasnoyarsk, Russia., Borovkova VS; School of Non-Ferrous Metals and Material Science, Siberian Federal University, Pr. Svobodny, 79, 660041 Krasnoyarsk, Russia.; Institute of Chemistry and Chemical Technology, Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok, 50/24, 660036 Krasnoyarsk, Russia., Skripnikov AM; School of Non-Ferrous Metals and Material Science, Siberian Federal University, Pr. Svobodny, 79, 660041 Krasnoyarsk, Russia.; Institute of Chemistry and Chemical Technology, Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok, 50/24, 660036 Krasnoyarsk, Russia., Miroshnikova AV; School of Non-Ferrous Metals and Material Science, Siberian Federal University, Pr. Svobodny, 79, 660041 Krasnoyarsk, Russia.; Institute of Chemistry and Chemical Technology, Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok, 50/24, 660036 Krasnoyarsk, Russia., Zimonin DV; School of Non-Ferrous Metals and Material Science, Siberian Federal University, Pr. Svobodny, 79, 660041 Krasnoyarsk, Russia.; Institute of Chemistry and Chemical Technology, Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok, 50/24, 660036 Krasnoyarsk, Russia., Ionin VA; School of Non-Ferrous Metals and Material Science, Siberian Federal University, Pr. Svobodny, 79, 660041 Krasnoyarsk, Russia.; Institute of Chemistry and Chemical Technology, Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok, 50/24, 660036 Krasnoyarsk, Russia., Kazachenko AS; School of Non-Ferrous Metals and Material Science, Siberian Federal University, Pr. Svobodny, 79, 660041 Krasnoyarsk, Russia., Issaoui N; Laboratory of Quantum and Statistical Physics (LR18ES18), Faculty of Sciences, University of Monastir, Monastir 5079, Tunisia.
Jazyk:	angličtina
Zdroj:	Molecules (Basel, Switzerland) [Molecules] 2021 Sep 03; Vol. 26 (17). Date of Electronic Publication: 2021 Sep 03.
DOI:	10.3390/molecules26175364
Abstrakt:	The process of sulfation of arabinogalactan-a natural polysaccharide from Larix sibirica Ledeb.- with sulfamic acid in 1,4-dioxane using different activators has been studied for the first time. The dynamics of the molecular weight of sulfated arabinogalactan upon variation in the temperature and time of sulfation of arabinogalactan with sulfamic acid in 1,4-dioxane has been investigated. It has been found that, as the sulfation time increases from 10 to 90 min, the molecular weights of the reaction products grow due to the introduction of sulfate groups without significant destruction of the initial polymer and sulfation products. Sulfation at 95 °C for 20 min yields the products with a higher molecular weight than in the case of sulfation at 85 °C, which is related to an increase in the sulfation rate; however, during the further process occurring under these conditions, sulfation is accompanied by the destruction and the molecular weight of the sulfated polymer decreases. The numerical optimization of arabinogalactan sulfation process has been performed. It has been shown that the optimal parameters for obtaining a product with a high sulfur content are a sulfamic acid amount of 20 mmol per 1 g of arabinogalactan, a process temperature of 85 °C, and a process time of 2.5 h.
Databáze:	MEDLINE
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