Benchmarking the ACEnano Toolbox for Characterisation of Nanoparticle Size and Concentration by Interlaboratory Comparisons.

Autor: Peters R; Wageningen Food Safety Research, Wageningen University & Research, Akkermaalsbos 2, 6708 WB Wageningen, The Netherlands., Elbers I; Wageningen Food Safety Research, Wageningen University & Research, Akkermaalsbos 2, 6708 WB Wageningen, The Netherlands., Undas A; Wageningen Food Safety Research, Wageningen University & Research, Akkermaalsbos 2, 6708 WB Wageningen, The Netherlands., Sijtsma E; Wageningen Food Safety Research, Wageningen University & Research, Akkermaalsbos 2, 6708 WB Wageningen, The Netherlands., Briffa S; School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, Carnell-Morris P; Malvern Panalytical, Enigma Business Park, Grovewood Road, Malvern, Worcestershire WR14 1XZ, UK, Siupa A; Malvern Panalytical, Enigma Business Park, Grovewood Road, Malvern, Worcestershire WR14 1XZ, UK, Yoon TH; Department of Chemistry, College of Natural Sciences, Hanyang University, Seoul 04763, Korea; Institute of Next Generation Material Design, Hanyang University, Seoul 04763, Korea, Burr L; CSEM, Centre Suisse d’Electronique et de Microtechnique SA, Bahnhofstrasse 1, 7302 Lanfquart, Switzerland, Schmid D; CSEM, Centre Suisse d’Electronique et de Microtechnique SA, Bahnhofstrasse 1, 7302 Lanfquart, Switzerland, Tentschert J; German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany, Hachenberger Y; German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany, Jungnickel H; German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany, Luch A; German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany, Meier F; Postnova Analytics GmbH, Rankine-Str. 1, 86899 Landsberg, Germany, Kocic J; Department of Chemistry and Applied Biosciences ETH Zurich, Vladimir-Prelog-Weg 1, 8093 Zurich, Switzerland, Kim J; Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon 34113, Korea, Park BC; Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon 34113, Korea, Hardy B; Edelweiss Connect GmbH, Technology Park Basel, Hochbergerstrasse 60C, 4057 Basel, Switzerland, Johnston C; Department of Materials, University of Oxford, Begbroke Science Park, Begbroke Hill, Oxford OX5 1PF, UK, Jurkschat K; Department of Materials, University of Oxford, Begbroke Science Park, Begbroke Hill, Oxford OX5 1PF, UK, Radnik J; Bundesanstalt für Materialforschung und-prüfung (BAM), Unter den Eichen 87, 12205 Berlin, Germany, Hodoroaba VD; Bundesanstalt für Materialforschung und-prüfung (BAM), Unter den Eichen 87, 12205 Berlin, Germany, Lynch I; School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, Valsami-Jones E; School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2021 Sep 01; Vol. 26 (17). Date of Electronic Publication: 2021 Sep 01.
DOI: 10.3390/molecules26175315
Abstrakt: ACEnano is an EU-funded project which aims at developing, optimising and validating methods for the detection and characterisation of nanomaterials (NMs) in increasingly complex matrices to improve confidence in the results and support their use in regulation. Within this project, several interlaboratory comparisons (ILCs) for the determination of particle size and concentration have been organised to benchmark existing analytical methods. In this paper the results of a number of these ILCs for the characterisation of NMs are presented and discussed. The results of the analyses of pristine well-defined particles such as 60 nm Au NMs in a simple aqueous suspension showed that laboratories are well capable of determining the sizes of these particles. The analysis of particles in complex matrices or formulations such as consumer products resulted in larger variations in particle sizes within technologies and clear differences in capability between techniques. Sunscreen lotion sample analysis by laboratories using spICP-MS and TEM/SEM identified and confirmed the TiO 2 particles as being nanoscale and compliant with the EU definition of an NM for regulatory purposes. In a toothpaste sample orthogonal results by PTA, spICP-MS and TEM/SEM agreed and stated the TiO 2 particles as not fitting the EU definition of an NM. In general, from the results of these ILCs we conclude that laboratories are well capable of determining particle sizes of NM, even in fairly complex formulations.
Databáze: MEDLINE
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