Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic.

Autor:	Jackson B; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK. Electronic address: ben.jackson@ed.ac.uk., Boni MF; Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, PA 16802, USA., Bull MJ; Pathogen Genomics Unit, Public Health Wales NHS Trust, Cardiff CF14 4AY, UK., Colleran A; Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK., Colquhoun RM; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK., Darby AC; Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK., Haldenby S; Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK., Hill V; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK., Lucaci A; Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK., McCrone JT; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK., Nicholls SM; The COVID-19 Genomics UK (COG-UK) Consortium, https://www.cogconsortium.uk/., O'Toole Á; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK., Pacchiarini N; Pathogen Genomics Unit, Public Health Wales NHS Trust, Cardiff CF14 4AY, UK., Poplawski R; The COVID-19 Genomics UK (COG-UK) Consortium, https://www.cogconsortium.uk/., Scher E; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK., Todd F; Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK., Webster HJ; Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK., Whitehead M; Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK., Wierzbicki C; Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK., Loman NJ; Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK., Connor TR; Pathogen Genomics Unit, Public Health Wales NHS Trust, Cardiff CF14 4AY, UK; School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK., Robertson DL; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow G61 1QH, UK., Pybus OG; Department of Zoology, University of Oxford, Oxford OX1 3SZ, UK; Department of Pathobiology and Population Sciences, The Royal Veterinary College, London AL9 7TA, UK., Rambaut A; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK. Electronic address: a.rambaut@ed.ac.uk.
Jazyk:	angličtina
Zdroj:	Cell [Cell] 2021 Sep 30; Vol. 184 (20), pp. 5179-5188.e8. Date of Electronic Publication: 2021 Aug 17.
DOI:	10.1016/j.cell.2021.08.014
Abstrakt:	We present evidence for multiple independent origins of recombinant SARS-CoV-2 viruses sampled from late 2020 and early 2021 in the United Kingdom. Their genomes carry single-nucleotide polymorphisms and deletions that are characteristic of the B.1.1.7 variant of concern but lack the full complement of lineage-defining mutations. Instead, the remainder of their genomes share contiguous genetic variation with non-B.1.1.7 viruses circulating in the same geographic area at the same time as the recombinants. In four instances, there was evidence for onward transmission of a recombinant-origin virus, including one transmission cluster of 45 sequenced cases over the course of 2 months. The inferred genomic locations of recombination breakpoints suggest that every community-transmitted recombinant virus inherited its spike region from a B.1.1.7 parental virus, consistent with a transmission advantage for B.1.1.7's set of mutations. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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